A molecular mechanism for sensory adaptation based on ligand-induced receptor modification

B. E. Knox, P. N. Devreotes, A. Goldbeter, L. A. Segel

Research output: Contribution to journalArticle

Abstract

Physiological responses mediated by cell-surface receptors frequently adapt or 'desensitize' (i.e., terminate despite persistent occupancy of receptors by ligand). Binding of ligands to the external domains of a wide variety of surface receptors induces covalent modification of their cytoplasmic domains. A mechanism is presented in which the variety of receptor states generated by ligand binding and covalent modification act together to regulate physiological responsiveness. The development of the model is guided by observations of adaptation for chemotaxis in Escherichia coli and adenylate cyclase activation in Dictyostelium. The general features of the marked response and eventual exact adaptation predicted by the model match those observed in the experimental systems.

Original languageEnglish (US)
Pages (from-to)2345-2349
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number8
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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