A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas

Godfree Mlambo, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

Plasma samples from patients undergoing treatment in malaria endemic countries often contain anti-malaria drugs, that may overstate effects of specific antibodies in growth inhibition assays (GIA). We describe a modified assay that uses drug resistant P. falciparum parasites (W2) that circumvents the requirement for dialyzing samples that may likely contain drugs such as chloroquine and sulfadoxine/pyrimethamine (SP).

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalExperimental Parasitology
Volume115
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Plasmodium falciparum
Malaria
Growth
Pharmaceutical Preparations
Chloroquine
Parasites
Antibodies
Therapeutics

Keywords

  • Growth inhibition assay
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

Cite this

A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas. / Mlambo, Godfree; Kumar, Nirbhay.

In: Experimental Parasitology, Vol. 115, No. 2, 02.2007, p. 211-214.

Research output: Contribution to journalArticle

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