A modified model of T-cell differentiation based on mTOR activity and metabolism

Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman

Research output: Contribution to journalArticle

Abstract

Current models of T-helper-cell differentiation depict the generation of effector cells from a naïve T cell based on the cytokine environment upon T-cell-receptor engagement. We propose a new model of CD4+ T-cell activation, differentiation, and function whereby the outcome of antigen recognition is dictated by mTOR activity and the subsequent up-regulation of selective metabolic function. Such a model more readily explains the generation of effector and memory cells including the concept of effector and memory Foxp3+ regulatory cells.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalCold Spring Harbor symposia on quantitative biology
Volume78
Issue number1
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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