A modified model of T-cell differentiation based on mTOR activity and metabolism

Jonathan Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman

Research output: Contribution to journalArticle

Abstract

Current models of T-helper-cell differentiation depict the generation of effector cells from a naïve T cell based on the cytokine environment upon T-cell-receptor engagement. We propose a new model of CD4+ T-cell activation, differentiation, and function whereby the outcome of antigen recognition is dictated by mTOR activity and the subsequent up-regulation of selective metabolic function. Such a model more readily explains the generation of effector and memory cells including the concept of effector and memory Foxp3+ regulatory cells.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume78
Issue number1
DOIs
StatePublished - 2013

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T-cells
Metabolism
Cell Differentiation
T-Lymphocytes
Data storage equipment
T-Cell Antigen Receptor
Up-Regulation
Chemical activation
Cytokines
Antigens

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Biochemistry
  • Medicine(all)

Cite this

A modified model of T-cell differentiation based on mTOR activity and metabolism. / Powell, Jonathan; Heikamp, Emily B.; Pollizzi, Kristen N.; Waickman, Adam T.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 78, No. 1, 2013, p. 125-130.

Research output: Contribution to journalArticle

Powell, Jonathan ; Heikamp, Emily B. ; Pollizzi, Kristen N. ; Waickman, Adam T. / A modified model of T-cell differentiation based on mTOR activity and metabolism. In: Cold Spring Harbor Symposia on Quantitative Biology. 2013 ; Vol. 78, No. 1. pp. 125-130.
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