A Modern Clinicopathological Approach to Traumatic Brain Injury

V. E. Koliatsos, L. Xu, J. Ryu, N. Ziogas

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


The clinicopathological method is a time-honored approach in scientific medicine that links bedside and pathological observations to pathophysiological hypotheses which then can be tested in models and turn up more refined hypotheses or, in best case scenarios, new diagnostics and therapeutics. Some neurological conditions, for example, neurodegenerative diseases and multiple sclerosis have already been through this cycle and, as a result, we now have an improved understanding of these illnesses and in some of them, for example, multiple sclerosis, we have significant therapeutic developments. The field of traumatic brain injury (TBI) is early in the clinicopathological process. Part of the reason is that TBI is an adversity, rather than single illness, that gives rise to diverse problems, many of which behave as chronic disease with varied outcomes. Achieving greater clarity in distinct morbidities, causes, mechanisms, hypotheses, and models is key before progress is made. The present stalemate in the field is partly due to failures in the implementation of the principles of scientific medicine.

Original languageEnglish (US)
Title of host publicationConn's Translational Neuroscience
PublisherElsevier Inc.
Number of pages21
ISBN (Electronic)9780128025963
ISBN (Print)9780128023815
StatePublished - Jan 1 2017


  • Blast injury
  • Brain contusion
  • Chronic traumatic encephalopathy
  • Concussion
  • Diffuse axonal injury
  • Neuroinflammation
  • Post-concussive syndrome
  • Posttraumatic stress disorder
  • Proteinopathy
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)


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