A Modern Clinicopathological Approach to Traumatic Brain Injury

Vassilis El Koliatsos, L. Xu, J. Ryu, N. Ziogas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The clinicopathological method is a time-honored approach in scientific medicine that links bedside and pathological observations to pathophysiological hypotheses which then can be tested in models and turn up more refined hypotheses or, in best case scenarios, new diagnostics and therapeutics. Some neurological conditions, for example, neurodegenerative diseases and multiple sclerosis have already been through this cycle and, as a result, we now have an improved understanding of these illnesses and in some of them, for example, multiple sclerosis, we have significant therapeutic developments. The field of traumatic brain injury (TBI) is early in the clinicopathological process. Part of the reason is that TBI is an adversity, rather than single illness, that gives rise to diverse problems, many of which behave as chronic disease with varied outcomes. Achieving greater clarity in distinct morbidities, causes, mechanisms, hypotheses, and models is key before progress is made. The present stalemate in the field is partly due to failures in the implementation of the principles of scientific medicine.

Original languageEnglish (US)
Title of host publicationConn's Translational Neuroscience
PublisherElsevier Inc.
Pages467-487
Number of pages21
ISBN (Electronic)9780128025963
ISBN (Print)9780128023815
DOIs
StatePublished - Oct 11 2016

Fingerprint

Multiple Sclerosis
Medicine
Neurodegenerative Diseases
Chronic Disease
Morbidity
Therapeutics
Traumatic Brain Injury

Keywords

  • Blast injury
  • Brain contusion
  • Chronic traumatic encephalopathy
  • Concussion
  • Diffuse axonal injury
  • Neuroinflammation
  • Post-concussive syndrome
  • Posttraumatic stress disorder
  • Proteinopathy
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Koliatsos, V. E., Xu, L., Ryu, J., & Ziogas, N. (2016). A Modern Clinicopathological Approach to Traumatic Brain Injury. In Conn's Translational Neuroscience (pp. 467-487). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802381-5.00033-6

A Modern Clinicopathological Approach to Traumatic Brain Injury. / Koliatsos, Vassilis El; Xu, L.; Ryu, J.; Ziogas, N.

Conn's Translational Neuroscience. Elsevier Inc., 2016. p. 467-487.

Research output: Chapter in Book/Report/Conference proceedingChapter

Koliatsos, VE, Xu, L, Ryu, J & Ziogas, N 2016, A Modern Clinicopathological Approach to Traumatic Brain Injury. in Conn's Translational Neuroscience. Elsevier Inc., pp. 467-487. https://doi.org/10.1016/B978-0-12-802381-5.00033-6
Koliatsos VE, Xu L, Ryu J, Ziogas N. A Modern Clinicopathological Approach to Traumatic Brain Injury. In Conn's Translational Neuroscience. Elsevier Inc. 2016. p. 467-487 https://doi.org/10.1016/B978-0-12-802381-5.00033-6
Koliatsos, Vassilis El ; Xu, L. ; Ryu, J. ; Ziogas, N. / A Modern Clinicopathological Approach to Traumatic Brain Injury. Conn's Translational Neuroscience. Elsevier Inc., 2016. pp. 467-487
@inbook{504b6744a7f046e39d6270e7f2c06f2f,
title = "A Modern Clinicopathological Approach to Traumatic Brain Injury",
abstract = "The clinicopathological method is a time-honored approach in scientific medicine that links bedside and pathological observations to pathophysiological hypotheses which then can be tested in models and turn up more refined hypotheses or, in best case scenarios, new diagnostics and therapeutics. Some neurological conditions, for example, neurodegenerative diseases and multiple sclerosis have already been through this cycle and, as a result, we now have an improved understanding of these illnesses and in some of them, for example, multiple sclerosis, we have significant therapeutic developments. The field of traumatic brain injury (TBI) is early in the clinicopathological process. Part of the reason is that TBI is an adversity, rather than single illness, that gives rise to diverse problems, many of which behave as chronic disease with varied outcomes. Achieving greater clarity in distinct morbidities, causes, mechanisms, hypotheses, and models is key before progress is made. The present stalemate in the field is partly due to failures in the implementation of the principles of scientific medicine.",
keywords = "Blast injury, Brain contusion, Chronic traumatic encephalopathy, Concussion, Diffuse axonal injury, Neuroinflammation, Post-concussive syndrome, Posttraumatic stress disorder, Proteinopathy, Traumatic brain injury",
author = "Koliatsos, {Vassilis El} and L. Xu and J. Ryu and N. Ziogas",
year = "2016",
month = "10",
day = "11",
doi = "10.1016/B978-0-12-802381-5.00033-6",
language = "English (US)",
isbn = "9780128023815",
pages = "467--487",
booktitle = "Conn's Translational Neuroscience",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - A Modern Clinicopathological Approach to Traumatic Brain Injury

AU - Koliatsos, Vassilis El

AU - Xu, L.

AU - Ryu, J.

AU - Ziogas, N.

PY - 2016/10/11

Y1 - 2016/10/11

N2 - The clinicopathological method is a time-honored approach in scientific medicine that links bedside and pathological observations to pathophysiological hypotheses which then can be tested in models and turn up more refined hypotheses or, in best case scenarios, new diagnostics and therapeutics. Some neurological conditions, for example, neurodegenerative diseases and multiple sclerosis have already been through this cycle and, as a result, we now have an improved understanding of these illnesses and in some of them, for example, multiple sclerosis, we have significant therapeutic developments. The field of traumatic brain injury (TBI) is early in the clinicopathological process. Part of the reason is that TBI is an adversity, rather than single illness, that gives rise to diverse problems, many of which behave as chronic disease with varied outcomes. Achieving greater clarity in distinct morbidities, causes, mechanisms, hypotheses, and models is key before progress is made. The present stalemate in the field is partly due to failures in the implementation of the principles of scientific medicine.

AB - The clinicopathological method is a time-honored approach in scientific medicine that links bedside and pathological observations to pathophysiological hypotheses which then can be tested in models and turn up more refined hypotheses or, in best case scenarios, new diagnostics and therapeutics. Some neurological conditions, for example, neurodegenerative diseases and multiple sclerosis have already been through this cycle and, as a result, we now have an improved understanding of these illnesses and in some of them, for example, multiple sclerosis, we have significant therapeutic developments. The field of traumatic brain injury (TBI) is early in the clinicopathological process. Part of the reason is that TBI is an adversity, rather than single illness, that gives rise to diverse problems, many of which behave as chronic disease with varied outcomes. Achieving greater clarity in distinct morbidities, causes, mechanisms, hypotheses, and models is key before progress is made. The present stalemate in the field is partly due to failures in the implementation of the principles of scientific medicine.

KW - Blast injury

KW - Brain contusion

KW - Chronic traumatic encephalopathy

KW - Concussion

KW - Diffuse axonal injury

KW - Neuroinflammation

KW - Post-concussive syndrome

KW - Posttraumatic stress disorder

KW - Proteinopathy

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85020170515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020170515&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-802381-5.00033-6

DO - 10.1016/B978-0-12-802381-5.00033-6

M3 - Chapter

SN - 9780128023815

SP - 467

EP - 487

BT - Conn's Translational Neuroscience

PB - Elsevier Inc.

ER -