A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus

Ying Cheng Lai, Raimond Winslow, Murray B. Sachs

Research output: Contribution to journalArticle

Abstract

Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs)at low stimulus levels, and that of high threshold, lowmedium SR ANFs at high stimulus levels. One hypothesis accounting for this phenomenon is that AVCN stellate cells selectively process inputs from different SR population of ANFs in a level-dependent fashion. In this paper, we investigate a neural mechanism that can support selective processing of ANF inputs by stellate cells. We study a physiologically detailed compartmental model of stellate cells. The model reproduces PST histograms and rate-versus-level functions measured in real cells. These results indicate that simple and plausible distribution patterns of excitatory and inhibitory inputs within the stellate cell dendritic tree can support level dependent selective processing. Factors affecting selective processing are identified. This study thus represents a first step towards the development of a computational model of the AVCN stellate cell receptive field.

Original languageEnglish (US)
Pages (from-to)167-194
Number of pages28
JournalJournal of Computational Neuroscience
Volume1
Issue number3
DOIs
StatePublished - Aug 1994

Fingerprint

Cochlear Nucleus
Cochlear Nerve
Nerve Fibers
Dendritic Cells
Cats
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus. / Lai, Ying Cheng; Winslow, Raimond; Sachs, Murray B.

In: Journal of Computational Neuroscience, Vol. 1, No. 3, 08.1994, p. 167-194.

Research output: Contribution to journalArticle

@article{3995912a997b4d749785017362881d67,
title = "A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus",
abstract = "Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs)at low stimulus levels, and that of high threshold, lowmedium SR ANFs at high stimulus levels. One hypothesis accounting for this phenomenon is that AVCN stellate cells selectively process inputs from different SR population of ANFs in a level-dependent fashion. In this paper, we investigate a neural mechanism that can support selective processing of ANF inputs by stellate cells. We study a physiologically detailed compartmental model of stellate cells. The model reproduces PST histograms and rate-versus-level functions measured in real cells. These results indicate that simple and plausible distribution patterns of excitatory and inhibitory inputs within the stellate cell dendritic tree can support level dependent selective processing. Factors affecting selective processing are identified. This study thus represents a first step towards the development of a computational model of the AVCN stellate cell receptive field.",
author = "Lai, {Ying Cheng} and Raimond Winslow and Sachs, {Murray B.}",
year = "1994",
month = "8",
doi = "10.1007/BF00961733",
language = "English (US)",
volume = "1",
pages = "167--194",
journal = "Journal of Computational Neuroscience",
issn = "0929-5313",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - A model of selective processing of auditory-nerve inputs by stellate cells of the antero-ventral cochlear nucleus

AU - Lai, Ying Cheng

AU - Winslow, Raimond

AU - Sachs, Murray B.

PY - 1994/8

Y1 - 1994/8

N2 - Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs)at low stimulus levels, and that of high threshold, lowmedium SR ANFs at high stimulus levels. One hypothesis accounting for this phenomenon is that AVCN stellate cells selectively process inputs from different SR population of ANFs in a level-dependent fashion. In this paper, we investigate a neural mechanism that can support selective processing of ANF inputs by stellate cells. We study a physiologically detailed compartmental model of stellate cells. The model reproduces PST histograms and rate-versus-level functions measured in real cells. These results indicate that simple and plausible distribution patterns of excitatory and inhibitory inputs within the stellate cell dendritic tree can support level dependent selective processing. Factors affecting selective processing are identified. This study thus represents a first step towards the development of a computational model of the AVCN stellate cell receptive field.

AB - Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs)at low stimulus levels, and that of high threshold, lowmedium SR ANFs at high stimulus levels. One hypothesis accounting for this phenomenon is that AVCN stellate cells selectively process inputs from different SR population of ANFs in a level-dependent fashion. In this paper, we investigate a neural mechanism that can support selective processing of ANF inputs by stellate cells. We study a physiologically detailed compartmental model of stellate cells. The model reproduces PST histograms and rate-versus-level functions measured in real cells. These results indicate that simple and plausible distribution patterns of excitatory and inhibitory inputs within the stellate cell dendritic tree can support level dependent selective processing. Factors affecting selective processing are identified. This study thus represents a first step towards the development of a computational model of the AVCN stellate cell receptive field.

UR - http://www.scopus.com/inward/record.url?scp=0028490338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028490338&partnerID=8YFLogxK

U2 - 10.1007/BF00961733

DO - 10.1007/BF00961733

M3 - Article

VL - 1

SP - 167

EP - 194

JO - Journal of Computational Neuroscience

JF - Journal of Computational Neuroscience

SN - 0929-5313

IS - 3

ER -