A model of fulminant hepatic failure in the rabbit

Bennett L. Blitzer; Jeanne G. Waggoner; E. Anthony Jones; Harvey R. Gralnick; David Towne; Jean Butler; Virginia Weise; Irwin J. Kopin; Ian Walters; Paul F. Teychenne; Dawn G. Goodman; Paul D. Berk

doi:10.1016/0016-5085(78)90241-x

A model of fulminant hepatic failure in the rabbit

Bennett L. Blitzer, Jeanne G. Waggoner, E. Anthony Jones, Harvey R. Gralnick, David Towne, Jean Butler, Virginia Weise, Irwin J. Kopin, Ian Walters, Paul F. Teychenne, Dawn G. Goodman, Paul D. Berk

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.

Original language	English (US)
Pages (from-to)	664-671
Number of pages	8
Journal	Gastroenterology
Volume	74
Issue number	4
DOIs	https://doi.org/10.1016/0016-5085(78)90241-x
State	Published - Apr 1978
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/0016-5085(78)90241-x

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title = "A model of fulminant hepatic failure in the rabbit",

abstract = "A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.",

author = "Blitzer, {Bennett L.} and Waggoner, {Jeanne G.} and Jones, {E. Anthony} and Gralnick, {Harvey R.} and David Towne and Jean Butler and Virginia Weise and Kopin, {Irwin J.} and Ian Walters and Teychenne, {Paul F.} and Goodman, {Dawn G.} and Berk, {Paul D.}",

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AU - Blitzer, Bennett L.

AU - Waggoner, Jeanne G.

AU - Jones, E. Anthony

AU - Gralnick, Harvey R.

AU - Towne, David

AU - Butler, Jean

AU - Weise, Virginia

AU - Kopin, Irwin J.

AU - Walters, Ian

AU - Teychenne, Paul F.

AU - Goodman, Dawn G.

AU - Berk, Paul D.

PY - 1978/4

Y1 - 1978/4

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AB - A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.

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A model of fulminant hepatic failure in the rabbit

Abstract

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