A model of fulminant hepatic failure in the rabbit

Bennett L. Blitzer, Jeanne G. Waggoner, E. Anthony Jones, Harvey R. Gralnick, David Towne, Jean Butler, Virginia Weise, Irwin J. Kopin, Ian Walters, Paul F. Teychenne, Dawn G. Goodman, Paul D. Berk

Research output: Contribution to journalArticle

Abstract

A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.

Original languageEnglish (US)
Pages (from-to)664-671
Number of pages8
JournalGastroenterology
Volume74
Issue number4
StatePublished - 1978
Externally publishedYes

Fingerprint

Acute Liver Failure
Rabbits
Galactosamine
Liver
Coma
Ammonia
Electroencephalography
Histology
Amino Acids
Injections
Wounds and Injuries
Serum
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Blitzer, B. L., Waggoner, J. G., Jones, E. A., Gralnick, H. R., Towne, D., Butler, J., ... Berk, P. D. (1978). A model of fulminant hepatic failure in the rabbit. Gastroenterology, 74(4), 664-671.

A model of fulminant hepatic failure in the rabbit. / Blitzer, Bennett L.; Waggoner, Jeanne G.; Jones, E. Anthony; Gralnick, Harvey R.; Towne, David; Butler, Jean; Weise, Virginia; Kopin, Irwin J.; Walters, Ian; Teychenne, Paul F.; Goodman, Dawn G.; Berk, Paul D.

In: Gastroenterology, Vol. 74, No. 4, 1978, p. 664-671.

Research output: Contribution to journalArticle

Blitzer, BL, Waggoner, JG, Jones, EA, Gralnick, HR, Towne, D, Butler, J, Weise, V, Kopin, IJ, Walters, I, Teychenne, PF, Goodman, DG & Berk, PD 1978, 'A model of fulminant hepatic failure in the rabbit', Gastroenterology, vol. 74, no. 4, pp. 664-671.
Blitzer BL, Waggoner JG, Jones EA, Gralnick HR, Towne D, Butler J et al. A model of fulminant hepatic failure in the rabbit. Gastroenterology. 1978;74(4):664-671.
Blitzer, Bennett L. ; Waggoner, Jeanne G. ; Jones, E. Anthony ; Gralnick, Harvey R. ; Towne, David ; Butler, Jean ; Weise, Virginia ; Kopin, Irwin J. ; Walters, Ian ; Teychenne, Paul F. ; Goodman, Dawn G. ; Berk, Paul D. / A model of fulminant hepatic failure in the rabbit. In: Gastroenterology. 1978 ; Vol. 74, No. 4. pp. 664-671.
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AU - Butler, Jean

AU - Weise, Virginia

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