A model of chronic nerve compression in the rat

J. P. O'Brien, S. E. Mackinnon, A. R. MacLean, A. R. Hudson, A. L. Dellon, D. A. Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

This article describes a model of chronic nerve compression in the rat. The sciatic nerve of adult male Sprague Dawley rats was banded with a 1-cm Silastic tube for varying periods of time. Morphometric analysis, electrodiagnostic studies, and histological evaluation were carried out 3, 5, 8, and 12 months after banding. Histological evaluation at 3 months was normal. At 5 months perineurial thickening was demonstrated. In the periphery of the fascicles, segmental demyelination was noted; central fibers appeared normal. At 8 months there was further epineurial and perineurial thickening. Marked thinning of the myelin was noted in the fibers and evidence of Wallerian degeneration was apparent. Progressive connective tissue and nerve fiber changes were noted at 12 months. Nerve conduction studies after 3 months of compression demonstrated an increase in conduction velocity compared to the normal unbanded control nerves. Progressive slowing of conduction velocity was noted from 5 through 12 months.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalAnnals of plastic surgery
Volume19
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'A model of chronic nerve compression in the rat'. Together they form a unique fingerprint.

Cite this