Abstract
Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-26 |
| Number of pages | 4 |
| Journal | Cancer Cells |
| Volume | 2 |
| Issue number | 1 |
| State | Published - 1990 |
ASJC Scopus subject areas
- Cancer Research