A model for quantitation of peritumoral brain edema

David E. Weissman; Stuart A. Grossman

doi:10.1016/0165-0270(88)90004-0

A model for quantitation of peritumoral brain edema

David E. Weissman, Stuart A. Grossman

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A model system is described which is suitable for quantitation of peritumoral brain edema. The temporal development of peritumoral brain edema in dexamethasone-treated rabbits and untreated controls was evaluated following the implantation of VX2 carcinoma cells into the frontal lobe of New Zealand White rabbits. A colorimetric assay of Evans blue (EB) extravasation was used to quantitate edema. Animals receiving a sham tumor injection contained an equal amount of EB compared to control animals. Dexamethasone was found to significantly reduce the extravasation of EB in rabbits with VX2 brain tumors and to delay the onset of neurologic deficits. These results are consistent with events occurring in patients with brain tumors. Studies of new drugs or physiologic aspects of peritumoral edema can be conducted with this model system.

Original language	English (US)
Pages (from-to)	207-210
Number of pages	4
Journal	Journal of Neuroscience Methods
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/0165-0270(88)90004-0
State	Published - Apr 1988
Externally published	Yes

Keywords

Brain edema
Brain neoplasm
Corticosteroid
Evans blue

ASJC Scopus subject areas

General Neuroscience

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10.1016/0165-0270(88)90004-0

Cite this

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title = "A model for quantitation of peritumoral brain edema",

abstract = "A model system is described which is suitable for quantitation of peritumoral brain edema. The temporal development of peritumoral brain edema in dexamethasone-treated rabbits and untreated controls was evaluated following the implantation of VX2 carcinoma cells into the frontal lobe of New Zealand White rabbits. A colorimetric assay of Evans blue (EB) extravasation was used to quantitate edema. Animals receiving a sham tumor injection contained an equal amount of EB compared to control animals. Dexamethasone was found to significantly reduce the extravasation of EB in rabbits with VX2 brain tumors and to delay the onset of neurologic deficits. These results are consistent with events occurring in patients with brain tumors. Studies of new drugs or physiologic aspects of peritumoral edema can be conducted with this model system.",

keywords = "Brain edema, Brain neoplasm, Corticosteroid, Evans blue",

author = "Weissman, {David E.} and Grossman, {Stuart A.}",

note = "Funding Information: D.E.W. is a recipient of the Bill O'Donnell Memorial Cancer Research Fellowship. S.A.G. is a recipient of the American Cancer Society Junior Faculty Clinical Fellowship award.",

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AU - Weissman, David E.

AU - Grossman, Stuart A.

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PY - 1988/4

Y1 - 1988/4

N2 - A model system is described which is suitable for quantitation of peritumoral brain edema. The temporal development of peritumoral brain edema in dexamethasone-treated rabbits and untreated controls was evaluated following the implantation of VX2 carcinoma cells into the frontal lobe of New Zealand White rabbits. A colorimetric assay of Evans blue (EB) extravasation was used to quantitate edema. Animals receiving a sham tumor injection contained an equal amount of EB compared to control animals. Dexamethasone was found to significantly reduce the extravasation of EB in rabbits with VX2 brain tumors and to delay the onset of neurologic deficits. These results are consistent with events occurring in patients with brain tumors. Studies of new drugs or physiologic aspects of peritumoral edema can be conducted with this model system.

AB - A model system is described which is suitable for quantitation of peritumoral brain edema. The temporal development of peritumoral brain edema in dexamethasone-treated rabbits and untreated controls was evaluated following the implantation of VX2 carcinoma cells into the frontal lobe of New Zealand White rabbits. A colorimetric assay of Evans blue (EB) extravasation was used to quantitate edema. Animals receiving a sham tumor injection contained an equal amount of EB compared to control animals. Dexamethasone was found to significantly reduce the extravasation of EB in rabbits with VX2 brain tumors and to delay the onset of neurologic deficits. These results are consistent with events occurring in patients with brain tumors. Studies of new drugs or physiologic aspects of peritumoral edema can be conducted with this model system.

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KW - Brain neoplasm

KW - Corticosteroid

KW - Evans blue

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A model for quantitation of peritumoral brain edema

Abstract

Keywords

ASJC Scopus subject areas

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