A model for quantitation of peritumoral brain edema

David E. Weissman, Stuart A. Grossman

Research output: Contribution to journalArticlepeer-review

Abstract

A model system is described which is suitable for quantitation of peritumoral brain edema. The temporal development of peritumoral brain edema in dexamethasone-treated rabbits and untreated controls was evaluated following the implantation of VX2 carcinoma cells into the frontal lobe of New Zealand White rabbits. A colorimetric assay of Evans blue (EB) extravasation was used to quantitate edema. Animals receiving a sham tumor injection contained an equal amount of EB compared to control animals. Dexamethasone was found to significantly reduce the extravasation of EB in rabbits with VX2 brain tumors and to delay the onset of neurologic deficits. These results are consistent with events occurring in patients with brain tumors. Studies of new drugs or physiologic aspects of peritumoral edema can be conducted with this model system.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalJournal of Neuroscience Methods
Volume23
Issue number3
DOIs
StatePublished - Apr 1988

Keywords

  • Brain edema
  • Brain neoplasm
  • Corticosteroid
  • Evans blue

ASJC Scopus subject areas

  • Neuroscience(all)

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