A model for pharmacological research-treatment of cocaine dependence

Ivan D. Montoya, Judith M. Hess, Kenzie L. Preston, David A. Gorelick

Research output: Contribution to journalArticle

Abstract

Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalJournal of Substance Abuse Treatment
Volume12
Issue number6
DOIs
StatePublished - 1995

Fingerprint

Cocaine-Related Disorders
Pharmacology
Research
Therapeutics
Reproducibility of Results
Research Design
Outpatients
Placebos
Clinical Trials
Pharmaceutical Preparations

Keywords

  • clinical trials
  • cocaine
  • dependence
  • model
  • pharmacotherapy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Phychiatric Mental Health
  • Clinical Psychology
  • Neuroscience(all)

Cite this

A model for pharmacological research-treatment of cocaine dependence. / Montoya, Ivan D.; Hess, Judith M.; Preston, Kenzie L.; Gorelick, David A.

In: Journal of Substance Abuse Treatment, Vol. 12, No. 6, 1995, p. 415-421.

Research output: Contribution to journalArticle

Montoya, Ivan D. ; Hess, Judith M. ; Preston, Kenzie L. ; Gorelick, David A. / A model for pharmacological research-treatment of cocaine dependence. In: Journal of Substance Abuse Treatment. 1995 ; Vol. 12, No. 6. pp. 415-421.
@article{c6173d0430954500a292a6af70dcda19,
title = "A model for pharmacological research-treatment of cocaine dependence",
abstract = "Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.",
keywords = "clinical trials, cocaine, dependence, model, pharmacotherapy",
author = "Montoya, {Ivan D.} and Hess, {Judith M.} and Preston, {Kenzie L.} and Gorelick, {David A.}",
year = "1995",
doi = "10.1016/0740-5472(95)02017-9",
language = "English (US)",
volume = "12",
pages = "415--421",
journal = "Journal of Substance Abuse Treatment",
issn = "0740-5472",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - A model for pharmacological research-treatment of cocaine dependence

AU - Montoya, Ivan D.

AU - Hess, Judith M.

AU - Preston, Kenzie L.

AU - Gorelick, David A.

PY - 1995

Y1 - 1995

N2 - Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.

AB - Major problems for research on pharmacological treatments for cocaine dependence are lack of comparability of results from different treatment research programs and poor validity and/or reliability of results. Double-blind, placebo-controlled, random assignment, experimental designs, using standard intake and assessment procedures help to reduce these problems. Cessation or reduction of drug use and/or craving, retention in treatment, and medical and psychosocial improvement are some of the outcome variables collected in treatment research programs. A model to be followed across different outpatient clinical trials for pharmacological treatment of cocaine dependence is presented here. This model represents an effort to standardize data collection to make results more valid and comparable.

KW - clinical trials

KW - cocaine

KW - dependence

KW - model

KW - pharmacotherapy

UR - http://www.scopus.com/inward/record.url?scp=0029561113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029561113&partnerID=8YFLogxK

U2 - 10.1016/0740-5472(95)02017-9

DO - 10.1016/0740-5472(95)02017-9

M3 - Article

C2 - 8749725

AN - SCOPUS:0029561113

VL - 12

SP - 415

EP - 421

JO - Journal of Substance Abuse Treatment

JF - Journal of Substance Abuse Treatment

SN - 0740-5472

IS - 6

ER -