A model for biliary and vascular access in the unanesthetized, unrestrained rat

Robert E. Epstein; Gene D. Branum; Giovanni Cucchiaro; William C. Meyers

doi:10.1016/0031-9384(90)90296-G

A model for biliary and vascular access in the unanesthetized, unrestrained rat

Robert E. Epstein, Gene D. Branum, Giovanni Cucchiaro, William C. Meyers

Research output: Contribution to journal › Article

Abstract

Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.

Original language	English (US)
Pages (from-to)	539-542
Number of pages	4
Journal	Physiology and Behavior
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(90)90296-G
State	Published - Oct 1990
Externally published	Yes

Keywords

Bile secretion
Gastrointestinal hormones
Rat
Vascular access

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(90)90296-G

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Epstein, R. E., Branum, G. D., Cucchiaro, G., & Meyers, W. C. (1990). A model for biliary and vascular access in the unanesthetized, unrestrained rat. Physiology and Behavior, 48(4), 539-542. https://doi.org/10.1016/0031-9384(90)90296-G

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