A model for biliary and vascular access in the unanesthetized, unrestrained rat

Robert E. Epstein, Gene D. Branum, Giovanni Cucchiaro, William C. Meyers

Research output: Contribution to journalArticle

Abstract

Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalPhysiology and Behavior
Volume48
Issue number4
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Blood Vessels
Bile
Catheterization
Anesthesia
Liver

Keywords

  • Bile secretion
  • Gastrointestinal hormones
  • Rat
  • Vascular access

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

A model for biliary and vascular access in the unanesthetized, unrestrained rat. / Epstein, Robert E.; Branum, Gene D.; Cucchiaro, Giovanni; Meyers, William C.

In: Physiology and Behavior, Vol. 48, No. 4, 01.01.1990, p. 539-542.

Research output: Contribution to journalArticle

Epstein, Robert E. ; Branum, Gene D. ; Cucchiaro, Giovanni ; Meyers, William C. / A model for biliary and vascular access in the unanesthetized, unrestrained rat. In: Physiology and Behavior. 1990 ; Vol. 48, No. 4. pp. 539-542.
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