A model for biliary and vascular access in the unanesthetized, unrestrained rat

Robert E. Epstein, Gene D. Branum, Giovanni Cucchiaro, William C. Meyers

Research output: Contribution to journalArticlepeer-review

Abstract

Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalPhysiology and Behavior
Volume48
Issue number4
DOIs
StatePublished - Oct 1990
Externally publishedYes

Keywords

  • Bile secretion
  • Gastrointestinal hormones
  • Rat
  • Vascular access

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'A model for biliary and vascular access in the unanesthetized, unrestrained rat'. Together they form a unique fingerprint.

Cite this