Abstract
Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 539-542 |
| Number of pages | 4 |
| Journal | Physiology and Behavior |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1990 |
| Externally published | Yes |
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Keywords
- Bile secretion
- Gastrointestinal hormones
- Rat
- Vascular access
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
Cite this
A model for biliary and vascular access in the unanesthetized, unrestrained rat. / Epstein, Robert E.; Branum, Gene D.; Cucchiaro, Giovanni; Meyers, William C.
In: Physiology and Behavior, Vol. 48, No. 4, 01.01.1990, p. 539-542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A model for biliary and vascular access in the unanesthetized, unrestrained rat
AU - Epstein, Robert E.
AU - Branum, Gene D.
AU - Cucchiaro, Giovanni
AU - Meyers, William C.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.
AB - Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.
KW - Bile secretion
KW - Gastrointestinal hormones
KW - Rat
KW - Vascular access
UR - http://www.scopus.com/inward/record.url?scp=0025048980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025048980&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(90)90296-G
DO - 10.1016/0031-9384(90)90296-G
M3 - Article
C2 - 2075205
AN - SCOPUS:0025048980
VL - 48
SP - 539
EP - 542
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 4
ER -