A minimal computational model for three-dimensional cell migration

Yuansheng Cao, Elisabeth Ghabache, Yuchuan Miao, Cassandra Niman, Hiroyuki Hakozaki, Samara L. Reck-Peterson, Peter N. Devreotes, Wouter Jan Rappel

Research output: Contribution to journalArticle

Abstract

During migration, eukaryotic cells can continuously change their three-dimensional morphology, resulting in a highly dynamic and complex process. Further complicating this process is the observation that the same cell type can rapidly switch between different modes of migration. Model-ling this complexity necessitates models that are able to track deforming membranes and that can capture the intracellular dynamics responsible for changes in migration modes. Here we develop an efficient three-dimensional computational model for cell migration, which couples cell mechanics to a simple intracellular activator-inhibitor signalling system. We compare the computational results to quantitative experiments using the social amoeba Dictyostelium discoideum. The model can reproduce the observed migration modes generated by varying either mechanical or biochemical model parameters and suggests a coupling between the substrate and the biomechanics of the cell.

Original languageEnglish (US)
Article number20190619
JournalJournal of the Royal Society Interface
Volume16
Issue number161
DOIs
StatePublished - Dec 1 2019

    Fingerprint

Keywords

  • Cell migration
  • Computational modelling
  • Dictyostelium
  • Migration mode

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Cao, Y., Ghabache, E., Miao, Y., Niman, C., Hakozaki, H., Reck-Peterson, S. L., Devreotes, P. N., & Rappel, W. J. (2019). A minimal computational model for three-dimensional cell migration. Journal of the Royal Society Interface, 16(161), [20190619]. https://doi.org/10.1098/rsif.2019.0619