A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

Research output: Contribution to journalArticlepeer-review

Abstract

The 4-[18F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[18F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume57
Issue number12
DOIs
StatePublished - Oct 2014

Keywords

  • Fluorine-18
  • Microwave
  • Phosphonium
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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