A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

Hayden T. Ravert; Daniel P. Holt; Robert F. Dannals

doi:10.1002/jlcr.3241

A microwave radiosynthesis of the 4-[¹⁸F]-fluorobenzyltriphenylphosphonium ion

Hayden T. Ravert, Daniel P. Holt, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The 4-[¹⁸F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [¹⁸F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[¹⁸F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.

Original language	English (US)
Pages (from-to)	695-698
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	57
Issue number	12
DOIs	https://doi.org/10.1002/jlcr.3241
State	Published - Oct 2014

Keywords

Fluorine-18
Microwave
Phosphonium
Positron emission tomography

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.3241

Cite this

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title = "A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion",

abstract = "The 4-[18F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[18F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.",

keywords = "Fluorine-18, Microwave, Phosphonium, Positron emission tomography",

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T1 - A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion

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AU - Holt, Daniel P.

AU - Dannals, Robert F.

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AB - The 4-[18F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [18F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[18F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/μmole at end of synthesis.

KW - Fluorine-18

KW - Microwave

KW - Phosphonium

KW - Positron emission tomography

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