A microtrap platform to investigate single cell mechanics

Qianru Jin, Gayatri Pahapale, Anil Bhatta, Aimee Dai, Lewis Romer, David H. Gracias

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a microfabricated microtrap platform for capture and micromechanics studies of single cells. Arrays of biocompatible glass-like three dimensional (3D) microtraps were engineered to capture single cells. By tuning lateral dimensions, thin film stress, and thickness of the traps, the extent of confinement and force on single cells could be tuned, allowing investigation of mechanics in 3D. The platform simultaneously allows optical and epifluorescence imaging of pre- and post-capture labeling, and parallel time lapse studies of cell dynamics induced by environmental changes.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages908-909
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • 3D
  • Biophysics
  • Cytoskeleton
  • Mechanotransduction
  • Micromechanics
  • Morphology
  • Nucleus

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Jin, Q., Pahapale, G., Bhatta, A., Dai, A., Romer, L., & Gracias, D. H. (2020). A microtrap platform to investigate single cell mechanics. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 908-909). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.