@inproceedings{4bcd21a5b21d433a86b93dc487763828,
title = "A microfluidic device for trapping and dynamic interrogation of arterioles",
abstract = "This paper reports the development of a microfluidic platform with a unique tapered microchannel geometry that incorporates a passive trapping mechanism to investigate flow in tiny fragile tubes such as arterioles, and organoid constructs modeled on small blood vessels. The platform facilitates an organ-specific continuous flow microenvironment that is conducive to optical imaging. The microfluidic device is fabricated by PDMS casting on 3D-printed molds to extend structural complexity, scale and tunability. The microfluidic platform is validated by the manipulation of 200-300 micron sized cell-laden self-rolled tubes with individual layers of human pulmonary artery smooth muscle cell (HPASMC)/microvascular endothelial cells (HPMEC).",
keywords = "3D printing, Blood vessel, Cell biology, Microfluidics, Tissue engineering",
author = "Xing Chen and Pagaduan, {Jayson V.} and Anil Bhatta and Gracias, {David H.} and Lewis Romer",
note = "Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
year = "2020",
language = "English (US)",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1112--1113",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
}