A microfluidic device for trapping and dynamic interrogation of arterioles

Xing Chen, Jayson V. Pagaduan, Anil Bhatta, David H. Gracias, Lewis Romer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports the development of a microfluidic platform with a unique tapered microchannel geometry that incorporates a passive trapping mechanism to investigate flow in tiny fragile tubes such as arterioles, and organoid constructs modeled on small blood vessels. The platform facilitates an organ-specific continuous flow microenvironment that is conducive to optical imaging. The microfluidic device is fabricated by PDMS casting on 3D-printed molds to extend structural complexity, scale and tunability. The microfluidic platform is validated by the manipulation of 200-300 micron sized cell-laden self-rolled tubes with individual layers of human pulmonary artery smooth muscle cell (HPASMC)/microvascular endothelial cells (HPMEC).

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1112-1113
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • 3D printing
  • Blood vessel
  • Cell biology
  • Microfluidics
  • Tissue engineering

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Chen, X., Pagaduan, J. V., Bhatta, A., Gracias, D. H., & Romer, L. (2020). A microfluidic device for trapping and dynamic interrogation of arterioles. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1112-1113). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.