@inproceedings{f4e925be850a400d93225294f2b3fe32,
title = "A microfluidic array of primary mammalian hepatocytes for use in high-throughput drug screening",
abstract = "Nearly half a billion dollars in resources are lost each time a drug candidate is withdrawn from the market by the Food and Drug Administration (FDA). The number of late-phase drug developmental failures due to liver toxicity could potentially be reduced through the use of hepatocyte-based systems capable of modelling the response of in vivo liver tissue to toxic insults. Here we report the development of a 64 (8×8) element array of microfluidic wells capable of supporting micropatterned primary rat hepatocytes in co-culture with 3T3-J2 fibroblasts.",
author = "Kane, {Bartholomew J.} and Zinner, {Michael J.} and Yarmush, {Martin L.} and Mehmet Toner",
year = "2005",
month = jan,
day = "1",
language = "English (US)",
isbn = "0974361119",
series = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Transducer Research Foundation",
pages = "421--423",
booktitle = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference",
note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",
}