A microfluidic array of primary mammalian hepatocytes for use in high-throughput drug screening

Bartholomew J. Kane, Michael J. Zinner, Martin L. Yarmush, Mehmet Toner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nearly half a billion dollars in resources are lost each time a drug candidate is withdrawn from the market by the Food and Drug Administration (FDA). The number of late-phase drug developmental failures due to liver toxicity could potentially be reduced through the use of hepatocyte-based systems capable of modelling the response of in vivo liver tissue to toxic insults. Here we report the development of a 64 (8×8) element array of microfluidic wells capable of supporting micropatterned primary rat hepatocytes in co-culture with 3T3-J2 fibroblasts.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages421-423
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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