A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

Tomoya Kitazume; Masatomo Asai; Takashi Tsukamoto; Takashi Yamazaki

doi:10.1016/S0022-1139(00)81174-4

A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

Tomoya Kitazume, Masatomo Asai, Takashi Tsukamoto, Takashi Yamazaki

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A synthetic approach to both enantiomers of the secondary alcohols [Ph(CH₂)_nCH(OH)CXF₂ (n=0-2) C₆H₁₃(CH₂)_nCH(OH)CFX₂ (n=0 or 2) and CXF₂CH(OH)CH₂CO₂Et [X=H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.

Original language	English (US)
Pages (from-to)	271-284
Number of pages	14
Journal	Journal of Fluorine Chemistry
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/S0022-1139(00)81174-4
State	Published - Mar 1992
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Environmental Chemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/S0022-1139(00)81174-4

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title = "A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group",

abstract = "A synthetic approach to both enantiomers of the secondary alcohols [Ph(CH2)nCH(OH)CXF2 (n=0-2) C6H13(CH2)nCH(OH)CFX2 (n=0 or 2) and CXF2CH(OH)CH2CO2Et [X=H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.",

author = "Tomoya Kitazume and Masatomo Asai and Takashi Tsukamoto and Takashi Yamazaki",

year = "1992",

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doi = "10.1016/S0022-1139(00)81174-4",

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pages = "271--284",

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T1 - A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

AU - Kitazume, Tomoya

AU - Asai, Masatomo

AU - Tsukamoto, Takashi

AU - Yamazaki, Takashi

PY - 1992/3

Y1 - 1992/3

N2 - A synthetic approach to both enantiomers of the secondary alcohols [Ph(CH2)nCH(OH)CXF2 (n=0-2) C6H13(CH2)nCH(OH)CFX2 (n=0 or 2) and CXF2CH(OH)CH2CO2Et [X=H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.

AB - A synthetic approach to both enantiomers of the secondary alcohols [Ph(CH2)nCH(OH)CXF2 (n=0-2) C6H13(CH2)nCH(OH)CFX2 (n=0 or 2) and CXF2CH(OH)CH2CO2Et [X=H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.

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VL - 56

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EP - 284

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

IS - 3

ER -

A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

Abstract

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