A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

Tomoya Kitazume, Masatomo Asai, Takashi Tsukamoto, Takashi Yamazaki

Research output: Contribution to journalArticlepeer-review

Abstract

A synthetic approach to both enantiomers of the secondary alcohols [Ph(CH2)nCH(OH)CXF2 (n=0-2) C6H13(CH2)nCH(OH)CFX2 (n=0 or 2) and CXF2CH(OH)CH2CO2Et [X=H or Cl], involving the stereoselective hydrolysis of ester derivatives, is described. The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.

Original languageEnglish (US)
Pages (from-to)271-284
Number of pages14
JournalJournal of Fluorine Chemistry
Volume56
Issue number3
DOIs
StatePublished - Mar 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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