TY - JOUR
T1 - A microbe-dependent viral key to Crohn's box
AU - Peterson, Daniel A.
AU - Turnbaugh, Peter J.
PY - 2010/8/4
Y1 - 2010/8/4
N2 - Once Pandora unlocked her fateful box and liberated the evil forces within, it became impossible to put them back. Now, new work on Crohn's disease suggests the existence of a viral "key" that irreversibly renders a genetically susceptible mouse prone to pathogenesis. Indeed, dangerous liaisons among host genotype, viral infection, intestinal injury, and trillions of gut microbes may in part determine which individuals progress to a full-blown disease state. These findings suggest that viral and bacterial triggers may serve as therapeutic targets for Crohn's and prompt new hypotheses that relate inflammation, host immune status, microbial community structure, and human health.
AB - Once Pandora unlocked her fateful box and liberated the evil forces within, it became impossible to put them back. Now, new work on Crohn's disease suggests the existence of a viral "key" that irreversibly renders a genetically susceptible mouse prone to pathogenesis. Indeed, dangerous liaisons among host genotype, viral infection, intestinal injury, and trillions of gut microbes may in part determine which individuals progress to a full-blown disease state. These findings suggest that viral and bacterial triggers may serve as therapeutic targets for Crohn's and prompt new hypotheses that relate inflammation, host immune status, microbial community structure, and human health.
UR - http://www.scopus.com/inward/record.url?scp=77955610809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955610809&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.3001422
DO - 10.1126/scitranslmed.3001422
M3 - Review article
C2 - 20686177
AN - SCOPUS:77955610809
SN - 1946-6234
VL - 2
JO - Science translational medicine
JF - Science translational medicine
IS - 43
M1 - 43ps39
ER -