A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Hans Jørgen Gundersen; Søren Baarsgaard Hansen; Albert Gjedde; Hans Stødkilde-Jørgensen; Jørgen Marqversen; Ralf Agger; Tom E. Andersen; Charlotte C. Fleischer; Mikkel Steen Petersen; Marianne Hokland; Egil Hulgaard; Jan Trøst Jørgensen; Ulrik Skands

doi:10.1117/12.535206

A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Hans Jørgen Gundersen, Søren Baarsgaard Hansen, Albert Gjedde, Hans Stødkilde-Jørgensen, Jørgen Marqversen, Ralf Agger, Tom E. Andersen, Charlotte C. Fleischer, Mikkel Steen Petersen, Marianne Hokland, Egil Hulgaard, Jan Trøst Jørgensen, Ulrik Skands

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

A method for precise and sensitive organ specific quantification of ¹²⁴I (¹²⁴IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.

Original language	English (US)
Pages (from-to)	361-370
Number of pages	10
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5369
DOIs	https://doi.org/10.1117/12.535206
State	Published - 2004
Externally published	Yes
Event	Medical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States Duration: Feb 15 2004 → Feb 17 2004

Keywords

Cell labelling
Image registration
MRI
PET
Small animal imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.535206

Cite this

Gundersen, H. J., Hansen, S. B., Gjedde, A., Stødkilde-Jørgensen, H., Marqversen, J., Agger, R., Andersen, T. E., Fleischer, C. C., Petersen, M. S., Hokland, M., Hulgaard, E., Jørgensen, J. T., & Skands, U. (2004). A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging. Proceedings of SPIE - The International Society for Optical Engineering, 5369, 361-370. https://doi.org/10.1117/12.535206

A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging. / Gundersen, Hans Jørgen; Hansen, Søren Baarsgaard; Gjedde, Albert et al.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 5369, 2004, p. 361-370.

Research output: Contribution to journal › Conference article › peer-review

Gundersen, HJ, Hansen, SB, Gjedde, A, Stødkilde-Jørgensen, H, Marqversen, J, Agger, R, Andersen, TE, Fleischer, CC, Petersen, MS, Hokland, M, Hulgaard, E, Jørgensen, JT & Skands, U 2004, 'A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging', Proceedings of SPIE - The International Society for Optical Engineering, vol. 5369, pp. 361-370. https://doi.org/10.1117/12.535206

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abstract = "A method for precise and sensitive organ specific quantification of 124I (124IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.",

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AU - Gundersen, Hans Jørgen

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AU - Stødkilde-Jørgensen, Hans

AU - Marqversen, Jørgen

AU - Agger, Ralf

AU - Andersen, Tom E.

AU - Fleischer, Charlotte C.

AU - Petersen, Mikkel Steen

AU - Hokland, Marianne

AU - Hulgaard, Egil

AU - Jørgensen, Jan Trøst

AU - Skands, Ulrik

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A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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