A methodology for quantifying and visualising cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Hans Jørgen Gundersen, Søren Baarsgaard Hansen, Albert Gjedde, Hans Stødkilde-Jørgensen, Jørgen Marqversen, Ralf Agger, Tom E. Andersen, Charlotte C. Fleischer, Mikkel Steen Petersen, Marianne Hokland, Egil Hulgaard, Jan Trøst Jørgensen, Ulrik Skands

Research output: Contribution to journalConference articlepeer-review

Abstract

A method for precise and sensitive organ specific quantification of 124I (124IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5369
DOIs
StatePublished - 2004
EventMedical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 15 2004Feb 17 2004

Keywords

  • Cell labelling
  • Image registration
  • MRI
  • PET
  • Small animal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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