A methodological approach to the prediction of anticancer drug effect in humans

W. J. Durkin, V. K. Ghanta, C. M. Balch, D. W. Davis, Charles M. Balch

Research output: Contribution to journalArticle

Abstract

Tumor cells from animals and humans were treated with drugs under tissue culture conditions. Tumor cells from the sensitive L1210 model were studied first. A dose-response curve was derived between drug exposure and subsequent cytotoxicity in L1210. The concentration of drug and duration of exposure were factors critical to the subsequent development of in vitro cytotoxicity. The in vitro dosage which effected 50% leukemic cell death in L1210 cells correlated with reported in vivo drug levels. Other tumor models and human neoplastic cells were studied at this dosage leel. A good correlation was noted in these studies between the in vivo responsiveness and the in vitro chemotherapy results in both animals and humans. It was suggested by these results that it may be possible to predict cancericidal drug activity for individual neoplasms by assaying in vitro for tumor cells i vitro fro drug sensitivity.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalCancer Research
Volume39
Issue number2 I
StatePublished - 1979
Externally publishedYes

Fingerprint

Pharmaceutical Preparations
Neoplasms
Cell Death
Drug Therapy
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Durkin, W. J., Ghanta, V. K., Balch, C. M., Davis, D. W., & Balch, C. M. (1979). A methodological approach to the prediction of anticancer drug effect in humans. Cancer Research, 39(2 I), 402-407.

A methodological approach to the prediction of anticancer drug effect in humans. / Durkin, W. J.; Ghanta, V. K.; Balch, C. M.; Davis, D. W.; Balch, Charles M.

In: Cancer Research, Vol. 39, No. 2 I, 1979, p. 402-407.

Research output: Contribution to journalArticle

Durkin, WJ, Ghanta, VK, Balch, CM, Davis, DW & Balch, CM 1979, 'A methodological approach to the prediction of anticancer drug effect in humans', Cancer Research, vol. 39, no. 2 I, pp. 402-407.
Durkin, W. J. ; Ghanta, V. K. ; Balch, C. M. ; Davis, D. W. ; Balch, Charles M. / A methodological approach to the prediction of anticancer drug effect in humans. In: Cancer Research. 1979 ; Vol. 39, No. 2 I. pp. 402-407.
@article{ab80250208974851b3dcf083b04b99ce,
title = "A methodological approach to the prediction of anticancer drug effect in humans",
abstract = "Tumor cells from animals and humans were treated with drugs under tissue culture conditions. Tumor cells from the sensitive L1210 model were studied first. A dose-response curve was derived between drug exposure and subsequent cytotoxicity in L1210. The concentration of drug and duration of exposure were factors critical to the subsequent development of in vitro cytotoxicity. The in vitro dosage which effected 50{\%} leukemic cell death in L1210 cells correlated with reported in vivo drug levels. Other tumor models and human neoplastic cells were studied at this dosage leel. A good correlation was noted in these studies between the in vivo responsiveness and the in vitro chemotherapy results in both animals and humans. It was suggested by these results that it may be possible to predict cancericidal drug activity for individual neoplasms by assaying in vitro for tumor cells i vitro fro drug sensitivity.",
author = "Durkin, {W. J.} and Ghanta, {V. K.} and Balch, {C. M.} and Davis, {D. W.} and Balch, {Charles M.}",
year = "1979",
language = "English (US)",
volume = "39",
pages = "402--407",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "2 I",

}

TY - JOUR

T1 - A methodological approach to the prediction of anticancer drug effect in humans

AU - Durkin, W. J.

AU - Ghanta, V. K.

AU - Balch, C. M.

AU - Davis, D. W.

AU - Balch, Charles M.

PY - 1979

Y1 - 1979

N2 - Tumor cells from animals and humans were treated with drugs under tissue culture conditions. Tumor cells from the sensitive L1210 model were studied first. A dose-response curve was derived between drug exposure and subsequent cytotoxicity in L1210. The concentration of drug and duration of exposure were factors critical to the subsequent development of in vitro cytotoxicity. The in vitro dosage which effected 50% leukemic cell death in L1210 cells correlated with reported in vivo drug levels. Other tumor models and human neoplastic cells were studied at this dosage leel. A good correlation was noted in these studies between the in vivo responsiveness and the in vitro chemotherapy results in both animals and humans. It was suggested by these results that it may be possible to predict cancericidal drug activity for individual neoplasms by assaying in vitro for tumor cells i vitro fro drug sensitivity.

AB - Tumor cells from animals and humans were treated with drugs under tissue culture conditions. Tumor cells from the sensitive L1210 model were studied first. A dose-response curve was derived between drug exposure and subsequent cytotoxicity in L1210. The concentration of drug and duration of exposure were factors critical to the subsequent development of in vitro cytotoxicity. The in vitro dosage which effected 50% leukemic cell death in L1210 cells correlated with reported in vivo drug levels. Other tumor models and human neoplastic cells were studied at this dosage leel. A good correlation was noted in these studies between the in vivo responsiveness and the in vitro chemotherapy results in both animals and humans. It was suggested by these results that it may be possible to predict cancericidal drug activity for individual neoplasms by assaying in vitro for tumor cells i vitro fro drug sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=0018417373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018417373&partnerID=8YFLogxK

M3 - Article

C2 - 761212

AN - SCOPUS:0018417373

VL - 39

SP - 402

EP - 407

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 2 I

ER -