A method to analyze correlations between multiple brain imaging tasks to characterize schizophrenia

Andrew M. Michael, Jill F. Fries, Stefi A. Baum, Beng C. Ho, Nancy C. Andreasen, Vince D. Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) is widely used to develop techniques to better understand brain disorders like schizophrenia. Due to the complexity of the disorder it is useful to fuse data collected while a subject performs different tasks. It has been hypothesized that schizophrenia is associated with disruptions in connectivity within brain regions. It has also been shown that schizophrenics activate more similarly to two different tasks than do controls. This paper introduces a novel technique to fuse data from multiple fMRI tasks taking into account all brain voxels. This approach evaluates the distributive nature of the disorder while fusing multitask data to identify if patients and controls activate differently. In a study involving three tasks it was found that patients with schizophrenia do activate more similarly to most of the combinations of tasks than do controls. Results also affirm that schizophrenia manifests with widespread functional changes over the whole brain.

Original languageEnglish (US)
Title of host publication2008 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2008 - Proceedings
Pages125-128
Number of pages4
DOIs
StatePublished - Dec 1 2008
Externally publishedYes
Event2008 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2008 - Santa Fe, NM, United States
Duration: Mar 24 2008Mar 26 2008

Publication series

NameProceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation

Other

Other2008 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2008
CountryUnited States
CitySanta Fe, NM
Period3/24/083/26/08

ASJC Scopus subject areas

  • Software
  • Computer Vision and Pattern Recognition
  • Computer Science Applications

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