A method of processing first-trimester chorionic villous biopsies for cytogenetic analysis

Karin Blakemore, M. S. Watson, J. Samuelson, W. R. Breg, M. J. Mahoney

Research output: Contribution to journalArticle

Abstract

Chorionic villous biopsy is emerging as a technique for obtaining fetal cells for prenatal diagnosis in the first trimester of pregnancy. Chromosome analysis has been performed on small villous biopsies using either direct harvests of uncultured cells or after culturing villous tissue. Here, we describe a method where both techniques can be used simultaneously; from a single villous biopsy, GTG-banded chromosomes of improved morphology are obtained from direct preparations and from cultured villous cells.

Original languageEnglish (US)
Pages (from-to)1386-1393
Number of pages8
JournalAmerican Journal of Human Genetics
Volume36
Issue number6
StatePublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Blakemore, K., Watson, M. S., Samuelson, J., Breg, W. R., & Mahoney, M. J. (1984). A method of processing first-trimester chorionic villous biopsies for cytogenetic analysis. American Journal of Human Genetics, 36(6), 1386-1393.