A method has been described which permits the quantitation of infarct size following experimental coronary artery occlusion. The results were surprisingly uniform, despite the observed anatomic variation in potential collateral circulation. Ligations of the anterior descending branch of the left coronary artery (LAD) at a high site produced infarcts 20 percent or greater in 7 of 8 dogs. A midpoint occlusion (between 1.1 and 2.6 cm. from the origin of the LAD) yielded infarcts between 13 percent and 18 percent in 6 of 8 dogs. All 8 animals with low ligations (3.5 cm. or beyond) had infarcts between 2 percent and 7 percent of the ventricular muscle mass. Several serum enzyme measurements were made in an attempt to correlate infarct size with degree of elevation. The SGOT and LDH values were studied most extensively because they appeared to be most sensitive. The modified LDH which represents the heart isozyme can be measured readily. Elevation of this latter enzyme correlates more closely with infarct size than any other serum enzyme determination.
|Original language||English (US)|
|Number of pages||9|
|State||Published - May 1 1964|
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