A metamorphosis distance for embryonic cardiac action potential interpolation and classification.

Giann Gorospe, Laurent Younes, Leslie Tung, René Vidal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of human embryonic stem cell cardiomyocytes (hESC-CMs) in tissue transplantation and repair has led to major recent advances in cardiac regenerative medicine. However, to avoid potential arrhythmias, it is critical that hESC-CMs used in replacement therapy be electrophysiologically compatible with the adult atrial, ventricular, and nodal phenotypes. The current method for classifying the electrophysiology of hESC-CMs relies mainly on the shape of the cell's action potential (AP), which each expert subjectively decides if it is nodal- like, atrial-like or ventricular-like. However, the classification is difficult because the shape of the AP of an hESC-CMs may not coincide with that of a mature cell. In this paper, we propose to use a metamorphosis distance for comparing the AP of an hESC-CMs to that of an adult cell model. This involves constructing a family of APs corresponding to different stages of the maturation process, and measuring the amount of deformation between APs. Experiments show that the proposed distance leads to better interpolation and classification results.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages469-476
Number of pages8
Volume16
EditionPt 1
StatePublished - 2013

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Cardiac Myocytes
Action Potentials
Tissue Transplantation
Regenerative Medicine
Cell Shape
Electrophysiology
Cardiac Arrhythmias
Human Embryonic Stem Cells
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gorospe, G., Younes, L., Tung, L., & Vidal, R. (2013). A metamorphosis distance for embryonic cardiac action potential interpolation and classification. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 1 ed., Vol. 16, pp. 469-476)

A metamorphosis distance for embryonic cardiac action potential interpolation and classification. / Gorospe, Giann; Younes, Laurent; Tung, Leslie; Vidal, René.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 1. ed. 2013. p. 469-476.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gorospe, G, Younes, L, Tung, L & Vidal, R 2013, A metamorphosis distance for embryonic cardiac action potential interpolation and classification. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 edn, vol. 16, pp. 469-476.
Gorospe G, Younes L, Tung L, Vidal R. A metamorphosis distance for embryonic cardiac action potential interpolation and classification. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 ed. Vol. 16. 2013. p. 469-476
Gorospe, Giann ; Younes, Laurent ; Tung, Leslie ; Vidal, René. / A metamorphosis distance for embryonic cardiac action potential interpolation and classification. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 16 Pt 1. ed. 2013. pp. 469-476
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