A metamorphosis distance for embryonic cardiac action potential interpolation and classification

Giann Gorospe, Laurent Younes, Leslie Tung, René Vidal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of human embryonic stem cell cardiomyocytes (hESC-CMs) in tissue transplantation and repair has led to major recent advances in cardiac regenerative medicine. However, to avoid potential arrhythmias, it is critical that hESC-CMs used in replacement therapy be electrophysiologically compatible with the adult atrial, ventricular, and nodal phenotypes. The current method for classifying the electrophysiology of hESC-CMs relies mainly on the shape of the cell's action potential (AP), which each expert subjectively decides if it is nodal-like, atrial-like or ventricular-like. However, the classification is difficult because the shape of the AP of an hESC-CMs may not coincide with that of a mature cell. In this paper, we propose to use a metamorphosis distance for comparing the AP of an hESC-CMs to that of an adult cell model. This involves constructing a family of APs corresponding to different stages of the maturation process, and measuring the amount of deformation between APs. Experiments show that the proposed distance leads to better interpolation and classification results.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2013 - 16th International Conference, Proceedings
Pages469-476
Number of pages8
EditionPART 1
DOIs
StatePublished - Oct 23 2013
Event16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013 - Nagoya, Japan
Duration: Sep 22 2013Sep 26 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume8149 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013
CountryJapan
CityNagoya
Period9/22/139/26/13

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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