A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease

Ida Sim, Munish Gupta, Kathryn McDonald, Martial G. Bourassa, Mark A. Hlatky

Research output: Contribution to journalArticle

Abstract

We performed a meta-analysis of randomized trials that compared percutaneous transluminal coronary angioplasty (PTCA) with coronary artery bypass graft (CABG) surgery in patients with multivessel coronary artery disease. The outcomes of death, combined death, and nonfatal myocardial infarction (MI), repeat revascularization, and freedom from angina were analyzed. The overall risk of death and nonfatal MI was not different over a follow-up of 1 to 3 years (CABG: PTCA odds ratio [OR] 1.03, 95% confidence interval 0.81 to 1.32, p = 0.81). Patients randomized to CABG tended to have a higher risk of death or MI in the early, periprocedural period (OR 1.33, p = 0.091), but a lower risk in subsequent follow-up (OR 0.74, p = 0.093). CABG patients were much less likely to undergo another revascularization procedure (p < 0.00001), and were more likely to be angina free (OR 1.57, p < 0.00001). Thus, CABG and PTCA patients have similar overall risks of death and nonfatal MI at 1 to 3 years of follow-up, but relative risk differences in mortality of up to 25% cannot be excluded. CABG patients have significantly less angina and less repeat revascularization than PTCA patients.

Original languageEnglish (US)
Pages (from-to)1025-1029
Number of pages5
JournalThe American journal of cardiology
Volume76
Issue number14
DOIs
StatePublished - Nov 15 1995
Externally publishedYes

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Coronary Balloon Angioplasty
Coronary Artery Bypass
Meta-Analysis
Coronary Artery Disease
Transplants
Odds Ratio
Myocardial Infarction
Confidence Intervals
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease. / Sim, Ida; Gupta, Munish; McDonald, Kathryn; Bourassa, Martial G.; Hlatky, Mark A.

In: The American journal of cardiology, Vol. 76, No. 14, 15.11.1995, p. 1025-1029.

Research output: Contribution to journalArticle

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