TY - JOUR
T1 - A meta-analysis of point-of-care laboratory tests in the diagnosis of novel 2009 swine-lineage pandemic influenza A (H1N1)
AU - Babin, Steven M.
AU - Hsieh, Yu Hsiang
AU - Rothman, Richard E.
AU - Gaydos, Charlotte A.
N1 - Funding Information:
This study was supported in part by the US Department of Homeland Security through a grant (N00014-06-0-0991) awarded to the National Center for Study of Preparedness and Critical Event Response (PACER) at Johns Hopkins University. Authors Rothman and Gaydos were also supported in part by the US National Institute of Allergy and Infectious Diseases Mid-Atlantic Regional Center of Excellence for Bio-defense and Emerging Infectious Diseases, Public Health Response Project VI, NIH grant U54-AI057168-06. Any opinions, findings, conclusions or recommendations expressed in this publication are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the United States Government or of Johns Hopkins University.
PY - 2011/4
Y1 - 2011/4
N2 - This paper reviews 14 published studies describing performance characteristics, including sensitivity and specificity, of commercially available rapid, point-of-care (POC) influenza tests in patients affected by an outbreak of a novel swine-related influenza A (H1N1) that was declared a pandemic in 2009. Although these POC tests were not intended to be specific for this pandemic influenza strain, the nonspecialized skills required and the timeliness of results make these POC tests potentially valuable for clinical and public health use. Pooled sensitivity and specificity for the POC tests studied were 68% and 81%, respectively, but published values were not homogeneous with sensitivities and specificities ranging from 10% to 88% and 51% to 100%, respectively. Pooled positive and negative likelihood ratios were 5.94 and 0.42, respectively. These results support current recommendations for use of rapid POC tests when H1N1 is suspected, recognizing that positive results are more reliable than negative results in determining infection, especially when disease prevalence is high.
AB - This paper reviews 14 published studies describing performance characteristics, including sensitivity and specificity, of commercially available rapid, point-of-care (POC) influenza tests in patients affected by an outbreak of a novel swine-related influenza A (H1N1) that was declared a pandemic in 2009. Although these POC tests were not intended to be specific for this pandemic influenza strain, the nonspecialized skills required and the timeliness of results make these POC tests potentially valuable for clinical and public health use. Pooled sensitivity and specificity for the POC tests studied were 68% and 81%, respectively, but published values were not homogeneous with sensitivities and specificities ranging from 10% to 88% and 51% to 100%, respectively. Pooled positive and negative likelihood ratios were 5.94 and 0.42, respectively. These results support current recommendations for use of rapid POC tests when H1N1 is suspected, recognizing that positive results are more reliable than negative results in determining infection, especially when disease prevalence is high.
KW - Influenza A (H1N1)
KW - Pandemic
KW - Rapid point-of-care test
KW - Swine origin
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U2 - 10.1016/j.diagmicrobio.2010.10.009
DO - 10.1016/j.diagmicrobio.2010.10.009
M3 - Article
C2 - 21396538
AN - SCOPUS:79952428931
SN - 0732-8893
VL - 69
SP - 410
EP - 418
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 4
ER -