TY - JOUR
T1 - A Meta-Analysis of Neuropsychological Functioning in the Logopenic Variant of Primary Progressive Aphasia
T2 - Comparison with the Semantic and Non-Fluent Variants
AU - Kamath, Vidyulata
AU - Sutherland, Emily R.
AU - Chaney, Grace Anna
N1 - Funding Information:
The views and opinions expressed in this article are those of the authors and should not be construed to represent the views of the US Government. The authors thank Martin D. Smith, M.A., Jonathan DeRight, Ph.D., Janae Cephas, Madalyn Myers, Erin Schnappauf, and Alana Spears for assistance with article procurement, data entry, and quality control checks of the data. VK is supported through the Johns Hopkins Clinical Research Scholars Program (grant number: KL2TR001077) and the Johns Hopkins Department of Psychiatry and Behavioral Sciences. The authors declare that they have no conflicts of interest.
Publisher Copyright:
© Copyright 2019 INS. Published by Cambridge University Press.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Objectives: The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA.Methods: We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges' g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA.Results: In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests.Conclusions: Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.
AB - Objectives: The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA.Methods: We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges' g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA.Results: In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests.Conclusions: Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.
KW - Alzheimer's disease
KW - Cognition
KW - Logopenic aphasia
KW - Memory
KW - Neuropsychological
KW - Primary progressive aphasia
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U2 - 10.1017/S1355617719001115
DO - 10.1017/S1355617719001115
M3 - Review article
C2 - 31658919
AN - SCOPUS:85081992747
SN - 1355-6177
VL - 26
SP - 322
EP - 330
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 3
ER -