A meta-analysis of emotion perception and functional outcomes in schizophrenia

Farzin Irani, Sarah Seligman, Vidyulata Kamath, Christian Kohler, Ruben C. Gur

Research output: Contribution to journalArticle

Abstract

Introduction: Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic strategy to combine results from several studies and examine synthesized effect sizes. Methods: A Meta-analysis of Observational Studies in Epidemiology standard was used to extract data following a PubMed and PsychInfo search. Studies reporting correlations between measures of EP and functional outcomes in schizophrenia spectrum disorders were selected. The impact of potential methodological (task type), demographic (sex, age, race, education, marital status) and clinical (age of onset, duration of illness, setting, symptoms, anti-psychotic medication) moderators on effect sizes were examined. Results: Twenty-five studies met inclusion criteria and included 1306 patients who were 37. years old, with 12. years of education, 64% male and 63% Caucasian. There was a significant relationship between EP and functional outcomes in individuals with schizophrenia or schizoaffective disorder, with effect sizes in the medium range. Medium to large range positive correlations were observed between emotion identification and functional outcome domains involving social problem solving, social skills and community functioning. Significant moderators included task type (emotion identification tasks), sex (% male in sample), race (% Caucasian in sample) and clinical symptoms (negative and positive). Conclusions: Emotion identification deficits are associated with functional impairments in schizophrenia and moderated by sex, race and symptoms. This has implications for treatment efforts to improve outcomes.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalSchizophrenia Research
Volume137
Issue number1-3
DOIs
StatePublished - May 2012
Externally publishedYes

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Meta-Analysis
Schizophrenia
Emotions
Education
Social Problems
Marital Status
Age of Onset
PubMed
Psychotic Disorders
Antipsychotic Agents
Observational Studies
Epidemiology
Demography
Therapeutics

Keywords

  • Emotion perception
  • Functional outcome
  • Meta-analysis
  • Quality of life
  • Schizophrenia
  • Social cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

A meta-analysis of emotion perception and functional outcomes in schizophrenia. / Irani, Farzin; Seligman, Sarah; Kamath, Vidyulata; Kohler, Christian; Gur, Ruben C.

In: Schizophrenia Research, Vol. 137, No. 1-3, 05.2012, p. 203-211.

Research output: Contribution to journalArticle

Irani, Farzin ; Seligman, Sarah ; Kamath, Vidyulata ; Kohler, Christian ; Gur, Ruben C. / A meta-analysis of emotion perception and functional outcomes in schizophrenia. In: Schizophrenia Research. 2012 ; Vol. 137, No. 1-3. pp. 203-211.
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