A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Ali Amin Al Olama; Zsofia Kote-Jarai; Sonja I. Berndt; David V. Conti; Fredrick Schumacher; Ying Han; Sara Benlloch; Dennis J. Hazelett; Zhaoming Wang; Ed Saunders; Daniel Leongamornlert; Sara Lindstrom; Sara Jugurnauth-Little; Tokhir Dadaev; Malgorzata Tymrakiewicz; Daniel O. Stram; Kristin Rand; Peggy Wan; Alex Stram; Xin Sheng; Loreall C. Pooler; Karen Park; Lucy Xia; Jonathan Tyrer; Laurence N. Kolonel; Loic Le Marchand; Robert N. Hoover; Mitchell J. Machiela; Merideth Yeager; Laurie Burdette; Charles C. Chung; Amy Hutchinson; Kai Yu; Chee Goh; Mahbubl Ahmed; Koveela Govindasami; Michelle Guy; Teuvo L.J. Tammela; Anssi Auvinen; Tiina Wahlfors; Johanna Schleutker; Tapio Visakorpi; Katri A. Leinonen; Jianfeng Xu; Markus Aly; Jenny Donovan; Ruth C. Travis; Tim J. Key; Afshan Siddiq; Federico Canzian; Kay Tee Khaw; Atsushi Takahashi; Michiaki Kubo; Paul Pharoah; Nora Pashayan; Maren Weischer; Borge G. Nordestgaard; Sune F. Nielsen; Peter Klarskov; Martin Andreas Røder; Peter Iversen; Stephen N. Thibodeau; Shannon K. McDonnell; Daniel J. Schaid; Janet L. Stanford; Suzanne Kolb; Sarah Holt; Beatrice Knudsen; Antonio Hurtado Coll; Susan M. Gapstur; W. Ryan Diver; Victoria L. Stevens; Christiane Maier; Manuel Luedeke; Kathleen Herkommer; Antje E. Rinckleb; Sara S. Strom; Curtis Pettaway; Edward D. Yeboah; Yao Tettey; Richard B. Biritwum; Andrew A. Adjei; Evelyn Tay; Ann Truelove; Shelley Niwa; Anand P. Chokkalingam; Lisa Cannon-Albright; Cezary Cybulski; Dominika Wokołorczyk; Wojciech Kluźniak; Jong Park; Thomas Sellers; Hui Yi Lin; William B. Isaacs; Alan W. Partin; Hermann Brenner; Aida Karina Dieffenbach; Christa Stegmaier; Constance Chen; Edward L. Giovannucci; Jing Ma; Meir Stampfer; Kathryn L. Penney; Lorelei Mucci; Esther M. John; Sue A. Ingles; Rick A. Kittles; Adam B. Murphy; Hardev Pandha; Agnieszka Michael; Andrzej M. Kierzek; William Blot; Lisa B. Signorello; Wei Zheng; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Barbara Nemesure; John Carpten; Cristina Leske; Suh Yuh Wu; Anselm Hennis; Adam S. Kibel; Benjamin A. Rybicki; Christine Neslund-Dudas; Ann W. Hsing; Lisa Chu; Phyllis J. Goodman; Eric A. Klein; S. Lilly Zheng; Jyotsna Batra; Judith Clements; Amanda Spurdle; Manuel R. Teixeira; Paula Paulo; Sofia Maia; Chavdar Slavov; Radka Kaneva; Vanio Mitev; John S. Witte; Graham Casey; Elizabeth M. Gillanders; Daniella Seminara; Elio Riboli; Freddie C. Hamdy; Gerhard A. Coetzee; Qiyuan Li; Matthew L. Freedman; David J. Hunter; Kenneth Muir; Henrik Gronberg; David E. Neal; Melissa Southey; Graham G. Giles; Gianluca Severi; Michael B. Cook; Hidewaki Nakagawa; Fredrik Wiklund; Peter Kraft; Stephen J. Chanock; Brian E. Henderson; Douglas F. Easton; Rosalind A. Eeles; Christopher A. Haiman

doi:10.1038/ng.3094

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I. Berndt, David V. Conti, Fredrick Schumacher, Ying Han, Sara Benlloch, Dennis J. Hazelett, Zhaoming Wang, Ed Saunders, Daniel Leongamornlert, Sara Lindstrom, Sara Jugurnauth-Little, Tokhir Dadaev, Malgorzata Tymrakiewicz, Daniel O. Stram, Kristin Rand, Peggy Wan, Alex Stram, Xin ShengLoreall C. Pooler, Karen Park, Lucy Xia, Jonathan Tyrer, Laurence N. Kolonel, Loic Le Marchand, Robert N. Hoover, Mitchell J. Machiela, Merideth Yeager, Laurie Burdette, Charles C. Chung, Amy Hutchinson, Kai Yu, Chee Goh, Mahbubl Ahmed, Koveela Govindasami, Michelle Guy, Teuvo L.J. Tammela, Anssi Auvinen, Tiina Wahlfors, Johanna Schleutker, Tapio Visakorpi, Katri A. Leinonen, Jianfeng Xu, Markus Aly, Jenny Donovan, Ruth C. Travis, Tim J. Key, Afshan Siddiq, Federico Canzian, Kay Tee Khaw, Atsushi Takahashi, Michiaki Kubo, Paul Pharoah, Nora Pashayan, Maren Weischer, Borge G. Nordestgaard, Sune F. Nielsen, Peter Klarskov, Martin Andreas Røder, Peter Iversen, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Janet L. Stanford, Suzanne Kolb, Sarah Holt, Beatrice Knudsen, Antonio Hurtado Coll, Susan M. Gapstur, W. Ryan Diver, Victoria L. Stevens, Christiane Maier, Manuel Luedeke, Kathleen Herkommer, Antje E. Rinckleb, Sara S. Strom, Curtis Pettaway, Edward D. Yeboah, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Anand P. Chokkalingam, Lisa Cannon-Albright, Cezary Cybulski, Dominika Wokołorczyk, Wojciech Kluźniak, Jong Park, Thomas Sellers, Hui Yi Lin, William B. Isaacs, Alan W. Partin, Hermann Brenner, Aida Karina Dieffenbach, Christa Stegmaier, Constance Chen, Edward L. Giovannucci, Jing Ma, Meir Stampfer, Kathryn L. Penney, Lorelei Mucci, Esther M. John, Sue A. Ingles, Rick A. Kittles, Adam B. Murphy, Hardev Pandha, Agnieszka Michael, Andrzej M. Kierzek, William Blot, Lisa B. Signorello, Wei Zheng, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Barbara Nemesure, John Carpten, Cristina Leske, Suh Yuh Wu, Anselm Hennis, Adam S. Kibel, Benjamin A. Rybicki, Christine Neslund-Dudas, Ann W. Hsing, Lisa Chu, Phyllis J. Goodman, Eric A. Klein, S. Lilly Zheng, Jyotsna Batra, Judith Clements, Amanda Spurdle, Manuel R. Teixeira, Paula Paulo, Sofia Maia, Chavdar Slavov, Radka Kaneva, Vanio Mitev, John S. Witte, Graham Casey, Elizabeth M. Gillanders, Daniella Seminara, Elio Riboli, Freddie C. Hamdy, Gerhard A. Coetzee, Qiyuan Li, Matthew L. Freedman, David J. Hunter, Kenneth Muir, Henrik Gronberg, David E. Neal, Melissa Southey, Graham G. Giles, Gianluca Severi, Michael B. Cook, Hidewaki Nakagawa, Fredrik Wiklund, Peter Kraft, Stephen J. Chanock, Brian E. Henderson, Douglas F. Easton, Rosalind A. Eeles, Christopher A. Haiman

School of Medicine

Research output: Contribution to journal › Article › peer-review

295 Scopus citations

Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10 â '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Original language	English (US)
Pages (from-to)	1103-1109
Number of pages	7
Journal	Nature genetics
Volume	46
Issue number	10
DOIs	https://doi.org/10.1038/ng.3094
State	Published - Sep 26 2014

ASJC Scopus subject areas

Genetics

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10.1038/ng.3094

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Olama, A. A. A., Kote-Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E., Leongamornlert, D., Lindstrom, S., Jugurnauth-Little, S., Dadaev, T., Tymrakiewicz, M., Stram, D. O., Rand, K., Wan, P., Stram, A., ... Haiman, C. A. (2014). A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nature genetics, 46(10), 1103-1109. https://doi.org/10.1038/ng.3094

Olama, AAA, Kote-Jarai, Z, Berndt, SI, Conti, DV, Schumacher, F, Han, Y, Benlloch, S, Hazelett, DJ, Wang, Z, Saunders, E, Leongamornlert, D, Lindstrom, S, Jugurnauth-Little, S, Dadaev, T, Tymrakiewicz, M, Stram, DO, Rand, K, Wan, P, Stram, A, Sheng, X, Pooler, LC, Park, K, Xia, L, Tyrer, J, Kolonel, LN, Marchand, LL, Hoover, RN, Machiela, MJ, Yeager, M, Burdette, L, Chung, CC, Hutchinson, A, Yu, K, Goh, C, Ahmed, M, Govindasami, K, Guy, M, Tammela, TLJ, Auvinen, A, Wahlfors, T, Schleutker, J, Visakorpi, T, Leinonen, KA, Xu, J, Aly, M, Donovan, J, Travis, RC, Key, TJ, Siddiq, A, Canzian, F, Khaw, KT, Takahashi, A, Kubo, M, Pharoah, P, Pashayan, N, Weischer, M, Nordestgaard, BG, Nielsen, SF, Klarskov, P, Røder, MA, Iversen, P, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Stanford, JL, Kolb, S, Holt, S, Knudsen, B, Coll, AH, Gapstur, SM, Diver, WR, Stevens, VL, Maier, C, Luedeke, M, Herkommer, K, Rinckleb, AE, Strom, SS, Pettaway, C, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, Cannon-Albright, L, Cybulski, C, Wokołorczyk, D, Kluźniak, W, Park, J, Sellers, T, Lin, HY, Isaacs, WB, Partin, AW, Brenner, H, Dieffenbach, AK, Stegmaier, C, Chen, C, Giovannucci, EL, Ma, J, Stampfer, M, Penney, KL, Mucci, L, John, EM, Ingles, SA, Kittles, RA, Murphy, AB, Pandha, H, Michael, A, Kierzek, AM, Blot, W, Signorello, LB, Zheng, W, Albanes, D, Virtamo, J, Weinstein, S, Nemesure, B, Carpten, J, Leske, C, Wu, SY, Hennis, A, Kibel, AS, Rybicki, BA, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Zheng, SL, Batra, J, Clements, J, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Slavov, C, Kaneva, R, Mitev, V, Witte, JS, Casey, G, Gillanders, EM, Seminara, D, Riboli, E, Hamdy, FC, Coetzee, GA, Li, Q, Freedman, ML, Hunter, DJ, Muir, K, Gronberg, H, Neal, DE, Southey, M, Giles, GG, Severi, G, Cook, MB, Nakagawa, H, Wiklund, F, Kraft, P, Chanock, SJ, Henderson, BE, Easton, DF, Eeles, RA & Haiman, CA 2014, 'A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer', Nature genetics, vol. 46, no. 10, pp. 1103-1109. https://doi.org/10.1038/ng.3094

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title = "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer",

abstract = "Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10 {\^a} '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.",

author = "Olama, {Ali Amin Al} and Zsofia Kote-Jarai and Berndt, {Sonja I.} and Conti, {David V.} and Fredrick Schumacher and Ying Han and Sara Benlloch and Hazelett, {Dennis J.} and Zhaoming Wang and Ed Saunders and Daniel Leongamornlert and Sara Lindstrom and Sara Jugurnauth-Little and Tokhir Dadaev and Malgorzata Tymrakiewicz and Stram, {Daniel O.} and Kristin Rand and Peggy Wan and Alex Stram and Xin Sheng and Pooler, {Loreall C.} and Karen Park and Lucy Xia and Jonathan Tyrer and Kolonel, {Laurence N.} and Marchand, {Loic Le} and Hoover, {Robert N.} and Machiela, {Mitchell J.} and Merideth Yeager and Laurie Burdette and Chung, {Charles C.} and Amy Hutchinson and Kai Yu and Chee Goh and Mahbubl Ahmed and Koveela Govindasami and Michelle Guy and Tammela, {Teuvo L.J.} and Anssi Auvinen and Tiina Wahlfors and Johanna Schleutker and Tapio Visakorpi and Leinonen, {Katri A.} and Jianfeng Xu and Markus Aly and Jenny Donovan and Travis, {Ruth C.} and Key, {Tim J.} and Afshan Siddiq and Federico Canzian and Khaw, {Kay Tee} and Atsushi Takahashi and Michiaki Kubo and Paul Pharoah and Nora Pashayan and Maren Weischer and Nordestgaard, {Borge G.} and Nielsen, {Sune F.} and Peter Klarskov and R{\o}der, {Martin Andreas} and Peter Iversen and Thibodeau, {Stephen N.} and McDonnell, {Shannon K.} and Schaid, {Daniel J.} and Stanford, {Janet L.} and Suzanne Kolb and Sarah Holt and Beatrice Knudsen and Coll, {Antonio Hurtado} and Gapstur, {Susan M.} and Diver, {W. Ryan} and Stevens, {Victoria L.} and Christiane Maier and Manuel Luedeke and Kathleen Herkommer and Rinckleb, {Antje E.} and Strom, {Sara S.} and Curtis Pettaway and Yeboah, {Edward D.} and Yao Tettey and Biritwum, {Richard B.} and Adjei, {Andrew A.} and Evelyn Tay and Ann Truelove and Shelley Niwa and Chokkalingam, {Anand P.} and Lisa Cannon-Albright and Cezary Cybulski and Dominika Woko{\l}orczyk and Wojciech Klu{\'z}niak and Jong Park and Thomas Sellers and Lin, {Hui Yi} and Isaacs, {William B.} and Partin, {Alan W.} and Hermann Brenner and Dieffenbach, {Aida Karina} and Christa Stegmaier and Constance Chen and Giovannucci, {Edward L.} and Jing Ma and Meir Stampfer and Penney, {Kathryn L.} and Lorelei Mucci and John, {Esther M.} and Ingles, {Sue A.} and Kittles, {Rick A.} and Murphy, {Adam B.} and Hardev Pandha and Agnieszka Michael and Kierzek, {Andrzej M.} and William Blot and Signorello, {Lisa B.} and Wei Zheng and Demetrius Albanes and Jarmo Virtamo and Stephanie Weinstein and Barbara Nemesure and John Carpten and Cristina Leske and Wu, {Suh Yuh} and Anselm Hennis and Kibel, {Adam S.} and Rybicki, {Benjamin A.} and Christine Neslund-Dudas and Hsing, {Ann W.} and Lisa Chu and Goodman, {Phyllis J.} and Klein, {Eric A.} and Zheng, {S. Lilly} and Jyotsna Batra and Judith Clements and Amanda Spurdle and Teixeira, {Manuel R.} and Paula Paulo and Sofia Maia and Chavdar Slavov and Radka Kaneva and Vanio Mitev and Witte, {John S.} and Graham Casey and Gillanders, {Elizabeth M.} and Daniella Seminara and Elio Riboli and Hamdy, {Freddie C.} and Coetzee, {Gerhard A.} and Qiyuan Li and Freedman, {Matthew L.} and Hunter, {David J.} and Kenneth Muir and Henrik Gronberg and Neal, {David E.} and Melissa Southey and Giles, {Graham G.} and Gianluca Severi and Cook, {Michael B.} and Hidewaki Nakagawa and Fredrik Wiklund and Peter Kraft and Chanock, {Stephen J.} and Henderson, {Brian E.} and Easton, {Douglas F.} and Eeles, {Rosalind A.} and Haiman, {Christopher A.}",

year = "2014",

month = sep,

day = "26",

doi = "10.1038/ng.3094",

language = "English (US)",

volume = "46",

pages = "1103--1109",

journal = "Nature genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

AU - Olama, Ali Amin Al

AU - Kote-Jarai, Zsofia

AU - Berndt, Sonja I.

AU - Conti, David V.

AU - Schumacher, Fredrick

AU - Han, Ying

AU - Benlloch, Sara

AU - Hazelett, Dennis J.

AU - Wang, Zhaoming

AU - Saunders, Ed

AU - Leongamornlert, Daniel

AU - Lindstrom, Sara

AU - Jugurnauth-Little, Sara

AU - Dadaev, Tokhir

AU - Tymrakiewicz, Malgorzata

AU - Stram, Daniel O.

AU - Rand, Kristin

AU - Wan, Peggy

AU - Stram, Alex

AU - Sheng, Xin

AU - Pooler, Loreall C.

AU - Park, Karen

AU - Xia, Lucy

AU - Tyrer, Jonathan

AU - Kolonel, Laurence N.

AU - Marchand, Loic Le

AU - Hoover, Robert N.

AU - Machiela, Mitchell J.

AU - Yeager, Merideth

AU - Burdette, Laurie

AU - Chung, Charles C.

AU - Hutchinson, Amy

AU - Yu, Kai

AU - Goh, Chee

AU - Ahmed, Mahbubl

AU - Govindasami, Koveela

AU - Guy, Michelle

AU - Tammela, Teuvo L.J.

AU - Auvinen, Anssi

AU - Wahlfors, Tiina

AU - Schleutker, Johanna

AU - Visakorpi, Tapio

AU - Leinonen, Katri A.

AU - Xu, Jianfeng

AU - Aly, Markus

AU - Donovan, Jenny

AU - Travis, Ruth C.

AU - Key, Tim J.

AU - Siddiq, Afshan

AU - Canzian, Federico

AU - Khaw, Kay Tee

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Pharoah, Paul

AU - Pashayan, Nora

AU - Weischer, Maren

AU - Nordestgaard, Borge G.

AU - Nielsen, Sune F.

AU - Klarskov, Peter

AU - Røder, Martin Andreas

AU - Iversen, Peter

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Stanford, Janet L.

AU - Kolb, Suzanne

AU - Holt, Sarah

AU - Knudsen, Beatrice

AU - Coll, Antonio Hurtado

AU - Gapstur, Susan M.

AU - Diver, W. Ryan

AU - Stevens, Victoria L.

AU - Maier, Christiane

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Rinckleb, Antje E.

AU - Strom, Sara S.

AU - Pettaway, Curtis

AU - Yeboah, Edward D.

AU - Tettey, Yao

AU - Biritwum, Richard B.

AU - Adjei, Andrew A.

AU - Tay, Evelyn

AU - Truelove, Ann

AU - Niwa, Shelley

AU - Chokkalingam, Anand P.

AU - Cannon-Albright, Lisa

AU - Cybulski, Cezary

AU - Wokołorczyk, Dominika

AU - Kluźniak, Wojciech

AU - Park, Jong

AU - Sellers, Thomas

AU - Lin, Hui Yi

AU - Isaacs, William B.

AU - Partin, Alan W.

AU - Brenner, Hermann

AU - Dieffenbach, Aida Karina

AU - Stegmaier, Christa

AU - Chen, Constance

AU - Giovannucci, Edward L.

AU - Ma, Jing

AU - Stampfer, Meir

AU - Penney, Kathryn L.

AU - Mucci, Lorelei

AU - John, Esther M.

AU - Ingles, Sue A.

AU - Kittles, Rick A.

AU - Murphy, Adam B.

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej M.

AU - Blot, William

AU - Signorello, Lisa B.

AU - Zheng, Wei

AU - Albanes, Demetrius

AU - Virtamo, Jarmo

AU - Weinstein, Stephanie

AU - Nemesure, Barbara

AU - Carpten, John

AU - Leske, Cristina

AU - Wu, Suh Yuh

AU - Hennis, Anselm

AU - Kibel, Adam S.

AU - Rybicki, Benjamin A.

AU - Neslund-Dudas, Christine

AU - Hsing, Ann W.

AU - Chu, Lisa

AU - Goodman, Phyllis J.

AU - Klein, Eric A.

AU - Zheng, S. Lilly

AU - Batra, Jyotsna

AU - Clements, Judith

AU - Spurdle, Amanda

AU - Teixeira, Manuel R.

AU - Paulo, Paula

AU - Maia, Sofia

AU - Slavov, Chavdar

AU - Kaneva, Radka

AU - Mitev, Vanio

AU - Witte, John S.

AU - Casey, Graham

AU - Gillanders, Elizabeth M.

AU - Seminara, Daniella

AU - Riboli, Elio

AU - Hamdy, Freddie C.

AU - Coetzee, Gerhard A.

AU - Li, Qiyuan

AU - Freedman, Matthew L.

AU - Hunter, David J.

AU - Muir, Kenneth

AU - Gronberg, Henrik

AU - Neal, David E.

AU - Southey, Melissa

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Cook, Michael B.

AU - Nakagawa, Hidewaki

AU - Wiklund, Fredrik

AU - Kraft, Peter

AU - Chanock, Stephen J.

AU - Henderson, Brian E.

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

AU - Haiman, Christopher A.

PY - 2014/9/26

Y1 - 2014/9/26

N2 - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10 â '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

AB - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10 â '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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U2 - 10.1038/ng.3094

DO - 10.1038/ng.3094

M3 - Article

C2 - 25217961

AN - SCOPUS:84922011640

SN - 1061-4036

VL - 46

SP - 1103

EP - 1109

JO - Nature genetics

JF - Nature genetics

IS - 10

ER -

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

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