A Mechanosensory System Controls Cell Shape Changes during Mitosis

Research output: Contribution to journalArticle

Abstract

Essential life processes are heavily controlled by a variety of positive and negative feedback systems. Cytokinesis failure, ultimately leading to aneuploidy, is appreciated as an early step in tumor formation in mammals and is deleterious for all cells. Further, the growing list of cancer predisposition mutations includes a number of genes whose proteins control mitosis and/or cytokinesis. Cytokinesis shape control is also an important part of pattern formation and cell-type specialization during multi-cellular development. Inherently mechanical, we hypothesized that mechanosensing and mechanical feedback are fundamental for cytokinesis shape regulation. Using mechanical perturbation, we identified a mechanosensory control system that monitors shape progression during cytokinesis. In this review, we summarize these findings and their implications for cytokinesis regulation and for understanding the cytoskeletal system architecture that governs shape control.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalCell cycle (Georgetown, Tex.)
Volume6
Issue number1
StatePublished - Jan 1 2007

Fingerprint

Cytokinesis
Cell Shape
Mitosis
Feedback
Control systems
Mammals
Tumors
Aneuploidy
Neoplasms
Proteins
Mutation

Keywords

  • Actin
  • Cell mechanics
  • Checkpoint
  • Control system
  • Cytokinesis
  • Mechanical feedback
  • Myosin-II

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

A Mechanosensory System Controls Cell Shape Changes during Mitosis. / Effler, Janet C.; Iglesias, Pablo A; Robinson, Douglas.

In: Cell cycle (Georgetown, Tex.), Vol. 6, No. 1, 01.01.2007, p. 30-35.

Research output: Contribution to journalArticle

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