A mechanistic theory to explain the efficacy of antiretroviral therapy

Sarah B. Laskey, Robert F Siliciano

Research output: Contribution to journalArticle

Abstract

In the early years of the AIDS epidemic, a diagnosis of HIV.1 infection was equivalent to a death sentence. The development of combination antiretroviral therapy (cART) in the 1990s to combat HIV.1 infection was one of the most impressive achievements of medical science. Today, patients who are treated early with cART can expect a near-normal lifespan. In this Opinion article, we propose a fundamental theory to explain the mechanistic basis of cART and why it works so well, including a model to assess and predict the efficacy of antiretroviral drugs alone or in combination.

Original languageEnglish (US)
Pages (from-to)772-780
Number of pages9
JournalNature Reviews Microbiology
Volume12
Issue number11
DOIs
StatePublished - Jan 1 2014

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Infection
Acquired Immunodeficiency Syndrome
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

A mechanistic theory to explain the efficacy of antiretroviral therapy. / Laskey, Sarah B.; Siliciano, Robert F.

In: Nature Reviews Microbiology, Vol. 12, No. 11, 01.01.2014, p. 772-780.

Research output: Contribution to journalArticle

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