A mechanistic overview of translation initiation in eukaryotes

Colin Echeverría Aitken, Jon R. Lorsch

Research output: Contribution to journalReview articlepeer-review


Translation initiation in eukaryotes is a complex and highly regulated process requiring the action of at least 12 protein factors. The pathway is distinguished by the formation of a pre-initiation complex that recruits the 5′ end of the mRNA and scans along it to locate the start codon. During the past decade, a combination of genetics, biochemistry and structural studies has begun to illuminate key molecular events in this critical phase of gene expression. Here, we outline our current understanding of eukaryotic translation initiation and discuss important outstanding challenges.

Original languageEnglish (US)
Pages (from-to)568-576
Number of pages9
JournalNature Structural and Molecular Biology
Issue number6
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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