@article{7d411484dff94fe5a7a2c2ff0169936f,
title = "A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer",
abstract = "Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPβ/Nf-II6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPβ in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.",
author = "Justin Lamb and Sridhar Ramaswamy and Ford, {Heide L.} and Bernardo Contreras and Martinez, {Robert V.} and Kittrell, {Frances S.} and Zahnow, {Cynthia A.} and Nick Patterson and Golub, {Todd R.} and Ewen, {Mark E.}",
note = "Funding Information: We thank Piotr Sicinski, Marian Walhout, and David Livingston for critical review of the manuscript, and Christine Ladd-Acosta and Carol Dacwag for technical assistance. We thank Simon Boulton, Marc Vidal, Massimo Loda, Phil Auron, Bert Vogelstein, Nelly Polyak, Dan Tenen, Mina Bissell, Jeff Rosen, Art Pardee, and Kenzo Ohtsuka for reagents and advice. This work was supported in part by grants from the Massachusetts Department of Public Health (to J.L.), Bristol-Myers Squibb, Affymetrix Inc., and Millennium Pharmaceuticals Inc. (to T.R.G.), and NIH grants APRC RO1-CA61253 (to H.L.F., T.R.G., and M.E.E.), CA88843 (to C.A.Z.), and PO1-CA80111 (to M.E.E.). J.L. is a Suzanne Sheats Breast Cancer Research Fellow. S.R. is the recipient of a Harvard/National Institutes of Health training grant in molecular hematology. H.L.F. is the recipient of a National Research Service Award (F32-CA79197). B.C. is supported by a Research Supplement for Underrepresented Minorities to the parent grant RO1-CA65842 (to M.E.E.). R.V.M. is the recipient of The Lady Tata Memorial Award. C.A.Z. is the inaugural Barbara B. Rubenstein Scholar. M.E.E. is a scholar for the Leukemia and Lymphoma Society.",
year = "2003",
month = aug,
day = "8",
doi = "10.1016/S0092-8674(03)00570-1",
language = "English (US)",
volume = "114",
pages = "323--334",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}