A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT

Xiaolei Song, Eric Frey, X. He, W. P. Segars, Benjamin Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have previously developed a model-based method to compensate for the crosstalk in simultaneous acquisition of Tc-99m stress and Tl-201 rest myocardial perfusion SPECT. The purpose of this study is to evaluate the performance of this method in terms of a defect detection task using a mathematical Channelized Hoteling Observer (CHO) study. In this study we also optimized the iteration number in reconstruction of Tl distributions. A population of male and female NCAT phantoms were used to realistically model variation in patients. Both defect-free and defect-present data of Tc and Tl were simulated using the SimSET/PHG codes and our newly developed and validated angular response function (ARF) method to mimic simultaneous acquisition and separate acquisition. Poisson noise was modeled at clinically realistic levels. The Tl data were reconstructed using filtered backprojection (FBP) and ordered subset expectation maximization (OSEM) algorithms for up to 20 iterations with and without the model-based crosstalk compensation (MBC). CHO methodology and receiver operating characteristic (ROC) analysis were applied to short axis Tl images to obtain ROC curves and area under ROC curves (AUC). The AUC values were compared with those from separately acquired data reconstructed using FBP and OSEM algorithms. The results show that a relatively small number of iteration (∼3) is optimal for the post-reconstruction filtering cutoff frequency of 0.16 pixel-1 used in this study. Also, the AUC values obtained with the MBC were significantly better than those without crosstalk compensation and those with the FBP reconstruction method applied to the separately acquired data.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
EditorsS.D. Metzler
Pages2521-2525
Number of pages5
Volume4
StatePublished - 2003
Event2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States
Duration: Oct 19 2003Oct 25 2003

Other

Other2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference
CountryUnited States
CityPortland, OR
Period10/19/0310/25/03

Fingerprint

Crosstalk
Isotopes
Set theory
Defects
Cutoff frequency
Pixels
Compensation and Redress

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Song, X., Frey, E., He, X., Segars, W. P., & Tsui, B. (2003). A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT. In S. D. Metzler (Ed.), IEEE Nuclear Science Symposium Conference Record (Vol. 4, pp. 2521-2525). [M9-4]

A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT. / Song, Xiaolei; Frey, Eric; He, X.; Segars, W. P.; Tsui, Benjamin.

IEEE Nuclear Science Symposium Conference Record. ed. / S.D. Metzler. Vol. 4 2003. p. 2521-2525 M9-4.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Song, X, Frey, E, He, X, Segars, WP & Tsui, B 2003, A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT. in SD Metzler (ed.), IEEE Nuclear Science Symposium Conference Record. vol. 4, M9-4, pp. 2521-2525, 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference, Portland, OR, United States, 10/19/03.
Song X, Frey E, He X, Segars WP, Tsui B. A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT. In Metzler SD, editor, IEEE Nuclear Science Symposium Conference Record. Vol. 4. 2003. p. 2521-2525. M9-4
Song, Xiaolei ; Frey, Eric ; He, X. ; Segars, W. P. ; Tsui, Benjamin. / A mathematical observer study for evaluation of a model-based compensation method for crosstalk in simultaneous dual isotope SPECT. IEEE Nuclear Science Symposium Conference Record. editor / S.D. Metzler. Vol. 4 2003. pp. 2521-2525
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