A lysosomal lair for a pathogenic protein pair

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects movement. Although many of the causes of PD remain unclear, a consistent finding is the abnormal accumulation of the protein α-synuclein. In a recent issue of Cell, Mazzuli et al. provide a molecular explanation for the unexpected link between PD and Gaucher's disease, a glycolipid lysosomal storage disorder caused by loss of the enzyme glucocerebrosidase (GBA). They report a reciprocal connection between loss of GBA activity and the accumulation of α-synuclein in lysosomes that establishes a bidirectional positive feedback loop with pathogenic consequences. Understanding how lysosomes are implicated in PD may reveal new therapeutic targets for treating this disease.

Original languageEnglish (US)
Article number91ps28
JournalScience translational medicine
Volume3
Issue number91
DOIs
StatePublished - Jul 13 2011

ASJC Scopus subject areas

  • Medicine(all)

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