A low-cost approach to measure the burden of vaccine preventable diseases in urban areas

Stephen P. Luby, Amal K. Halder, Samir K. Saha, Aliya Naheed, Hossain M.S. Sazzad, Shamima Akhter, Emily S. Gurley, W. Abdullah Brooks, Shams El-Arifeen, Nusrat Najnin, Arifa Nazneen, Robert F. Breiman

Research output: Contribution to journalArticlepeer-review

Abstract

We piloted a low-cost approach to measure the disease burden of Streptococcus pneumoniae, Hib and Salmonella Typhi by leveraging the existing infrastructure of high performing microbiology laboratories at two large paediatric hospitals in Dhaka Bangladesh, and assessing the hospital utilization of the catchment population of these hospitals for different syndromes. S. Typhi was the most common bacterium identified in culture and accounted for an estimated 211 hospitalizations per 100,000 children <5 years of age per year. Meningitis due to S. pneumoniae was the most common cause of mortality accounting for 8.0 deaths per 100,000 children <5 years of age per year. This low-cost approach can provide data to support vaccine introduction and the health impact of newly introduced vaccines.

Original languageEnglish (US)
Pages (from-to)4903-4912
Number of pages10
JournalVaccine
Volume28
Issue number31
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • Haemophilus influenzae type B
  • Meningitis
  • Pneumonia
  • Streptococcus pneumoniae
  • Surveillance
  • Typhoid fever

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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