A low-cost approach to measure the burden of vaccine preventable diseases in urban areas

Stephen P. Luby; Amal K. Halder; Samir K. Saha; Aliya Naheed; Hossain M.S. Sazzad; Shamima Akhter; Emily S. Gurley; W. Abdullah Brooks; Shams El-Arifeen; Nusrat Najnin; Arifa Nazneen; Robert F. Breiman

doi:10.1016/j.vaccine.2010.05.040

A low-cost approach to measure the burden of vaccine preventable diseases in urban areas

Stephen P. Luby, Amal K. Halder, Samir K. Saha, Aliya Naheed, Hossain M.S. Sazzad, Shamima Akhter, Emily S. Gurley, W. Abdullah Brooks, Shams El-Arifeen, Nusrat Najnin, Arifa Nazneen, Robert F. Breiman

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We piloted a low-cost approach to measure the disease burden of Streptococcus pneumoniae, Hib and Salmonella Typhi by leveraging the existing infrastructure of high performing microbiology laboratories at two large paediatric hospitals in Dhaka Bangladesh, and assessing the hospital utilization of the catchment population of these hospitals for different syndromes. S. Typhi was the most common bacterium identified in culture and accounted for an estimated 211 hospitalizations per 100,000 children <5 years of age per year. Meningitis due to S. pneumoniae was the most common cause of mortality accounting for 8.0 deaths per 100,000 children <5 years of age per year. This low-cost approach can provide data to support vaccine introduction and the health impact of newly introduced vaccines.

Original language	English (US)
Pages (from-to)	4903-4912
Number of pages	10
Journal	Vaccine
Volume	28
Issue number	31
DOIs	https://doi.org/10.1016/j.vaccine.2010.05.040
State	Published - Jul 2010
Externally published	Yes

Keywords

Haemophilus influenzae type B
Meningitis
Pneumonia
Streptococcus pneumoniae
Surveillance
Typhoid fever

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2010.05.040

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title = "A low-cost approach to measure the burden of vaccine preventable diseases in urban areas",

abstract = "We piloted a low-cost approach to measure the disease burden of Streptococcus pneumoniae, Hib and Salmonella Typhi by leveraging the existing infrastructure of high performing microbiology laboratories at two large paediatric hospitals in Dhaka Bangladesh, and assessing the hospital utilization of the catchment population of these hospitals for different syndromes. S. Typhi was the most common bacterium identified in culture and accounted for an estimated 211 hospitalizations per 100,000 children <5 years of age per year. Meningitis due to S. pneumoniae was the most common cause of mortality accounting for 8.0 deaths per 100,000 children <5 years of age per year. This low-cost approach can provide data to support vaccine introduction and the health impact of newly introduced vaccines.",

keywords = "Haemophilus influenzae type B, Meningitis, Pneumonia, Streptococcus pneumoniae, Surveillance, Typhoid fever",

author = "Luby, {Stephen P.} and Halder, {Amal K.} and Saha, {Samir K.} and Aliya Naheed and Sazzad, {Hossain M.S.} and Shamima Akhter and Gurley, {Emily S.} and Brooks, {W. Abdullah} and Shams El-Arifeen and Nusrat Najnin and Arifa Nazneen and Breiman, {Robert F.}",

note = "Funding Information: This work was funded by the Department of Health and Human Services National Vaccine Program Office (NVPO) through the United States Agency for International Development Global Bureau's Global Research Activity Cooperative Agreement with Johns Hopkins University Bloomberg School of Public Health , and the Government of Bangladesh through IHP-HNPRP . ICDDR,B acknowledges with gratitude the commitment of NVPO and IHP-HNPRP to the Centre's research efforts. The authors appreciate the suggestions made by Brendan Flannery, Danny Feikin, and John A. Crump to the study protocol, the consistent professional efforts of the field team especially Mamun-Ar-Rashid, Iffat Sharmin and Kazi Faisal Alam, and the careful laboratory work of Rajan Debnath. ",

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AU - Halder, Amal K.

AU - Saha, Samir K.

AU - Naheed, Aliya

AU - Sazzad, Hossain M.S.

AU - Akhter, Shamima

AU - Gurley, Emily S.

AU - Brooks, W. Abdullah

AU - El-Arifeen, Shams

AU - Najnin, Nusrat

AU - Nazneen, Arifa

AU - Breiman, Robert F.

N1 - Funding Information: This work was funded by the Department of Health and Human Services National Vaccine Program Office (NVPO) through the United States Agency for International Development Global Bureau's Global Research Activity Cooperative Agreement with Johns Hopkins University Bloomberg School of Public Health , and the Government of Bangladesh through IHP-HNPRP . ICDDR,B acknowledges with gratitude the commitment of NVPO and IHP-HNPRP to the Centre's research efforts. The authors appreciate the suggestions made by Brendan Flannery, Danny Feikin, and John A. Crump to the study protocol, the consistent professional efforts of the field team especially Mamun-Ar-Rashid, Iffat Sharmin and Kazi Faisal Alam, and the careful laboratory work of Rajan Debnath.

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N2 - We piloted a low-cost approach to measure the disease burden of Streptococcus pneumoniae, Hib and Salmonella Typhi by leveraging the existing infrastructure of high performing microbiology laboratories at two large paediatric hospitals in Dhaka Bangladesh, and assessing the hospital utilization of the catchment population of these hospitals for different syndromes. S. Typhi was the most common bacterium identified in culture and accounted for an estimated 211 hospitalizations per 100,000 children <5 years of age per year. Meningitis due to S. pneumoniae was the most common cause of mortality accounting for 8.0 deaths per 100,000 children <5 years of age per year. This low-cost approach can provide data to support vaccine introduction and the health impact of newly introduced vaccines.

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KW - Haemophilus influenzae type B

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KW - Streptococcus pneumoniae

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KW - Typhoid fever

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A low-cost approach to measure the burden of vaccine preventable diseases in urban areas

Abstract

Keywords

ASJC Scopus subject areas

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