A loop resonator for slice-selective in vivo EPR imaging in rats

Hiroshi Hirata, Guanglong He, Yuanmu Deng, Ildar Salikhov, Sergey Petryakov, Jay L. Zweier

Research output: Contribution to journalArticlepeer-review

Abstract

A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.

Original languageEnglish (US)
Pages (from-to)124-134
Number of pages11
JournalJournal of Magnetic Resonance
Volume190
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • In vivo EPR imaging
  • Rat
  • Resonator
  • RF magnetic field
  • Slice-selective image

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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