A loop resonator for slice-selective in vivo EPR imaging in rats

Hiroshi Hirata; Guanglong He; Yuanmu Deng; Ildar Salikhov; Sergey Petryakov; Jay L. Zweier

doi:10.1016/j.jmr.2007.10.012

A loop resonator for slice-selective in vivo EPR imaging in rats

Hiroshi Hirata, Guanglong He, Yuanmu Deng, Ildar Salikhov, Sergey Petryakov, Jay L. Zweier

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W^1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.

Original language	English (US)
Pages (from-to)	124-134
Number of pages	11
Journal	Journal of Magnetic Resonance
Volume	190
Issue number	1
DOIs	https://doi.org/10.1016/j.jmr.2007.10.012
State	Published - Jan 2008
Externally published	Yes

Keywords

In vivo EPR imaging
Rat
Resonator
RF magnetic field
Slice-selective image

ASJC Scopus subject areas

Molecular Biology
Physical and Theoretical Chemistry
Spectroscopy
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/j.jmr.2007.10.012

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title = "A loop resonator for slice-selective in vivo EPR imaging in rats",

abstract = "A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.",

keywords = "In vivo EPR imaging, Rat, Resonator, RF magnetic field, Slice-selective image",

author = "Hiroshi Hirata and Guanglong He and Yuanmu Deng and Ildar Salikhov and Sergey Petryakov and Zweier, {Jay L.}",

year = "2008",

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T1 - A loop resonator for slice-selective in vivo EPR imaging in rats

AU - Hirata, Hiroshi

AU - He, Guanglong

AU - Deng, Yuanmu

AU - Salikhov, Ildar

AU - Petryakov, Sergey

AU - Zweier, Jay L.

PY - 2008/1

Y1 - 2008/1

N2 - A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.

AB - A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.

KW - In vivo EPR imaging

KW - Rat

KW - Resonator

KW - RF magnetic field

KW - Slice-selective image

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ER -

A loop resonator for slice-selective in vivo EPR imaging in rats

Abstract

Keywords

ASJC Scopus subject areas

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