A loop resonator for slice-selective in vivo EPR imaging in rats

Hiroshi Hirata, Guanglong He, Yuanmu Deng, Ildar Salikhov, Sergey Petryakov, Jay L. Zweier

Research output: Contribution to journalArticle

Abstract

A loop resonator was developed for 300 MHz continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy and imaging in live rats. A single-turn loop (55 mm in diameter) was used to provide sufficient space for the rat body. Efficiency for generating a radiofrequency magnetic field of 38 μT/W1/2 was achieved at the center of the loop. For the resonator itself, an unloaded quality factor of 430 was obtained. When a 350 g rat was placed in the resonator at the level of the lower abdomen, the quality factor decreased to 18. The sensitive volume in the loop was visualized with a bottle filled with an aqueous solution of the nitroxide spin probe 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy (3-CP). The resonator was shown to enable EPR imaging in live rats. Imaging was performed for 3-CP that had been infused intravenously into the rat and its distribution was visualized within the lower abdomen.

Original languageEnglish (US)
Pages (from-to)124-134
Number of pages11
JournalJournal of Magnetic Resonance
Volume190
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

rats
Paramagnetic resonance
Rats
Resonators
resonators
Imaging techniques
abdomen
Abdomen
Q factors
bottles
Electron Spin Resonance Spectroscopy
Bottles
Magnetic Fields
continuous radiation
Spectrum Analysis
electron paramagnetic resonance
Spectroscopy
Magnetic fields
aqueous solutions
probes

Keywords

  • In vivo EPR imaging
  • Rat
  • Resonator
  • RF magnetic field
  • Slice-selective image

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Hirata, H., He, G., Deng, Y., Salikhov, I., Petryakov, S., & Zweier, J. L. (2008). A loop resonator for slice-selective in vivo EPR imaging in rats. Journal of Magnetic Resonance, 190(1), 124-134. https://doi.org/10.1016/j.jmr.2007.10.012

A loop resonator for slice-selective in vivo EPR imaging in rats. / Hirata, Hiroshi; He, Guanglong; Deng, Yuanmu; Salikhov, Ildar; Petryakov, Sergey; Zweier, Jay L.

In: Journal of Magnetic Resonance, Vol. 190, No. 1, 01.2008, p. 124-134.

Research output: Contribution to journalArticle

Hirata, H, He, G, Deng, Y, Salikhov, I, Petryakov, S & Zweier, JL 2008, 'A loop resonator for slice-selective in vivo EPR imaging in rats', Journal of Magnetic Resonance, vol. 190, no. 1, pp. 124-134. https://doi.org/10.1016/j.jmr.2007.10.012
Hirata, Hiroshi ; He, Guanglong ; Deng, Yuanmu ; Salikhov, Ildar ; Petryakov, Sergey ; Zweier, Jay L. / A loop resonator for slice-selective in vivo EPR imaging in rats. In: Journal of Magnetic Resonance. 2008 ; Vol. 190, No. 1. pp. 124-134.
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