A lock on phosphotyrosine signaling

Kathryn E. Muratore, Philip A. Cole

Research output: Contribution to journalArticlepeer-review

Abstract

Protein phosphorylation plays a major role in cell signaling and human disease, so understanding the effects of tyrosine phosphorylation on protein structure and function is an area of intense investigation. A new technique allows site-specific incorporation of a nonhydrolyzable phosphotyrosine analogue into recombinant proteins, providing a new strategy for research in this important area.

Original languageEnglish (US)
Pages (from-to)454-456
Number of pages3
JournalACS chemical biology
Volume2
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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