A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

Kristen K. Pierce; Stephen S. Whitehead; Beth D. Kirkpatrick; Palmtama L. Grier; Adrienne Jarvis; Heather Kenney; Marya P. Carmolli; Cynthia Reynolds; Cecilia M. Tibery; Janece Lovchik; Anna Janiak; Catherine J. Luke; Anna P. Durbin; Alexander G. Pletnev

doi:10.1093/infdis/jiw501

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

Kristen K. Pierce, Stephen S. Whitehead, Beth D. Kirkpatrick, Palmtama L. Grier, Adrienne Jarvis, Heather Kenney, Marya P. Carmolli, Cynthia Reynolds, Cecilia M. Tibery, Janece Lovchik, Anna Janiak, Catherine J. Luke, Anna P. Durbin, Alexander G. Pletnev

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

Original language	English (US)
Pages (from-to)	52-55
Number of pages	4
Journal	The Journal of infectious diseases
Volume	215
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiw501
State	Published - Jan 1 2017

Keywords

West Nile virus
flavivirus
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiw501

Fingerprint Dive into the research topics of 'A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers'. Together they form a unique fingerprint.

Cite this

Pierce, K. K., Whitehead, S. S., Kirkpatrick, B. D., Grier, P. L., Jarvis, A., Kenney, H., Carmolli, M. P., Reynolds, C., Tibery, C. M., Lovchik, J., Janiak, A., Luke, C. J., Durbin, A. P., & Pletnev, A. G. (2017). A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. The Journal of infectious diseases, 215(1), 52-55. https://doi.org/10.1093/infdis/jiw501

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. / Pierce, Kristen K.; Whitehead, Stephen S.; Kirkpatrick, Beth D.; Grier, Palmtama L.; Jarvis, Adrienne; Kenney, Heather; Carmolli, Marya P.; Reynolds, Cynthia; Tibery, Cecilia M.; Lovchik, Janece; Janiak, Anna; Luke, Catherine J.; Durbin, Anna P.; Pletnev, Alexander G.

In: The Journal of infectious diseases, Vol. 215, No. 1, 01.01.2017, p. 52-55.

Research output: Contribution to journal › Article › peer-review

Pierce, KK, Whitehead, SS, Kirkpatrick, BD, Grier, PL, Jarvis, A, Kenney, H, Carmolli, MP, Reynolds, C, Tibery, CM, Lovchik, J, Janiak, A, Luke, CJ, Durbin, AP & Pletnev, AG 2017, 'A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers', The Journal of infectious diseases, vol. 215, no. 1, pp. 52-55. https://doi.org/10.1093/infdis/jiw501

Pierce, Kristen K. ; Whitehead, Stephen S. ; Kirkpatrick, Beth D. ; Grier, Palmtama L. ; Jarvis, Adrienne ; Kenney, Heather ; Carmolli, Marya P. ; Reynolds, Cynthia ; Tibery, Cecilia M. ; Lovchik, Janece ; Janiak, Anna ; Luke, Catherine J. ; Durbin, Anna P. ; Pletnev, Alexander G. / A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers. In: The Journal of infectious diseases. 2017 ; Vol. 215, No. 1. pp. 52-55.

@article{20eaebdb5c7841318e85b9f21194f4ae,

title = "A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers",

abstract = "West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.",

keywords = "West Nile virus, flavivirus, vaccine",

author = "Pierce, {Kristen K.} and Whitehead, {Stephen S.} and Kirkpatrick, {Beth D.} and Grier, {Palmtama L.} and Adrienne Jarvis and Heather Kenney and Carmolli, {Marya P.} and Cynthia Reynolds and Tibery, {Cecilia M.} and Janece Lovchik and Anna Janiak and Luke, {Catherine J.} and Durbin, {Anna P.} and Pletnev, {Alexander G.}",

note = "Publisher Copyright: {\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com. Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "2017",

month = jan,

day = "1",

doi = "10.1093/infdis/jiw501",

language = "English (US)",

volume = "215",

pages = "52--55",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

AU - Pierce, Kristen K.

AU - Whitehead, Stephen S.

AU - Kirkpatrick, Beth D.

AU - Grier, Palmtama L.

AU - Jarvis, Adrienne

AU - Kenney, Heather

AU - Carmolli, Marya P.

AU - Reynolds, Cynthia

AU - Tibery, Cecilia M.

AU - Lovchik, Janece

AU - Janiak, Anna

AU - Luke, Catherine J.

AU - Durbin, Anna P.

AU - Pletnev, Alexander G.

N1 - Publisher Copyright: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com. Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2017/1/1

Y1 - 2017/1/1

N2 - West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

AB - West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

KW - West Nile virus

KW - flavivirus

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=85039761806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039761806&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiw501

DO - 10.1093/infdis/jiw501

M3 - Article

C2 - 28077583

AN - SCOPUS:85039761806

VL - 215

SP - 52

EP - 55

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -