A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

Chester A. Mathis, Brian J. Bacskai, Stephen T. Kajdasz, Megan E. McLellan, Matthew P. Frosch, Bradley T. Hyman, Daniel Holt, Yanming Wang, Guo Feng Huang, Manik L. Debnath, William E. Klunk

Research output: Contribution to journalArticle

Abstract

The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [11C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [11C]6 is a promising amyloid imaging agent for Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number3
DOIs
StatePublished - Feb 11 2002
Externally publishedYes

Fingerprint

Positron emission tomography
Amyloid
Positron-Emission Tomography
Brain
Derivatives
Imaging techniques
Amyloid Plaques
Intravenous Injections
Transgenic Mice
Microscopy
Alzheimer Disease
Injections
Microscopic examination
Deposits
thioflavin T
benzothiazole

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Mathis, C. A., Bacskai, B. J., Kajdasz, S. T., McLellan, M. E., Frosch, M. P., Hyman, B. T., ... Klunk, W. E. (2002). A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorganic and Medicinal Chemistry Letters, 12(3), 295-298. https://doi.org/10.1016/S0960-894X(01)00734-X

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. / Mathis, Chester A.; Bacskai, Brian J.; Kajdasz, Stephen T.; McLellan, Megan E.; Frosch, Matthew P.; Hyman, Bradley T.; Holt, Daniel; Wang, Yanming; Huang, Guo Feng; Debnath, Manik L.; Klunk, William E.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 3, 11.02.2002, p. 295-298.

Research output: Contribution to journalArticle

Mathis, CA, Bacskai, BJ, Kajdasz, ST, McLellan, ME, Frosch, MP, Hyman, BT, Holt, D, Wang, Y, Huang, GF, Debnath, ML & Klunk, WE 2002, 'A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 3, pp. 295-298. https://doi.org/10.1016/S0960-894X(01)00734-X
Mathis, Chester A. ; Bacskai, Brian J. ; Kajdasz, Stephen T. ; McLellan, Megan E. ; Frosch, Matthew P. ; Hyman, Bradley T. ; Holt, Daniel ; Wang, Yanming ; Huang, Guo Feng ; Debnath, Manik L. ; Klunk, William E. / A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 3. pp. 295-298.
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