A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

Chester A. Mathis, Brian J. Bacskai, Stephen T. Kajdasz, Megan E. McLellan, Matthew P. Frosch, Bradley T. Hyman, Daniel P. Holt, Yanming Wang, Guo Feng Huang, Manik L. Debnath, William E. Klunk

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of a new lipophilic thioflavin-T analogue (2-[4′-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [11C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [11C]6 is a promising amyloid imaging agent for Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)295-298
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number3
DOIs
StatePublished - Feb 11 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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