TY - JOUR
T1 - A linkage map of human chromosome 21
T2 - 43 PCR markers at average intervals of 2.5 cM
AU - Mcinnis, Melvin
AU - Chakravarti, Aravinda
AU - Blaschak, Jillian
AU - Petersen, Michael B.
AU - Sharma, Vikram
AU - Avramopoulos, Dimitrios
AU - Blouin, Jean Louis
AU - König, Ulrich
AU - Brahe, Christina
AU - Matise, Tara Cox
AU - Warren, Andrew C.
AU - Talbot, C Conover
AU - Van Broeckhoven, Christine
AU - Litt, Michael
AU - Antonarakis, Stylianos E.
PY - 1993/6
Y1 - 1993/6
N2 - A genetic linkage map of human chromosome 21q (HC21q) containing 43 markers genotyped by the polymerase chain reaction in the CEPH pedigrees is presented. The markers placed on this map are highly polymorphic with an average heterozygosity of 61%. The average interval size of the markers localized at 1000:1 odds is 2.5 cM. The map has a total length of 65.5 cM, with male and female lengths of 47.7 and 83.3 cM, respectively. The genotypes used in the construction of this map were subjected to rigorous error checking, which is reflected in the shorter map length compared to previous maps; the estimated error rate in genotyping is less than 0.04%. As noted in previous linkage maps there is increased recombination in females on proximal HC 21q and in the male in a region near the telomere. This map of HC 21 represents a highly informative and dense meiotic linkage map and will be useful in linking disease phenotypes to loci on this chromosome.
AB - A genetic linkage map of human chromosome 21q (HC21q) containing 43 markers genotyped by the polymerase chain reaction in the CEPH pedigrees is presented. The markers placed on this map are highly polymorphic with an average heterozygosity of 61%. The average interval size of the markers localized at 1000:1 odds is 2.5 cM. The map has a total length of 65.5 cM, with male and female lengths of 47.7 and 83.3 cM, respectively. The genotypes used in the construction of this map were subjected to rigorous error checking, which is reflected in the shorter map length compared to previous maps; the estimated error rate in genotyping is less than 0.04%. As noted in previous linkage maps there is increased recombination in females on proximal HC 21q and in the male in a region near the telomere. This map of HC 21 represents a highly informative and dense meiotic linkage map and will be useful in linking disease phenotypes to loci on this chromosome.
UR - http://www.scopus.com/inward/record.url?scp=0027308708&partnerID=8YFLogxK
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U2 - 10.1006/geno.1993.1231
DO - 10.1006/geno.1993.1231
M3 - Article
C2 - 8325627
AN - SCOPUS:0027308708
VL - 16
SP - 562
EP - 571
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -