A linkage map of human chromosome 21: 43 PCR markers at average intervals of 2.5 cM

Melvin G. McInnis, Aravinda Chakravarti, Jillian Blaschak, Michael B. Petersen, Vikram Sharma, Dimitrios Avramopoulos, Jean Louis Blouin, Ulrich König, Christina Brahe, Tara Cox Matise, Andrew C. Warren, C. Conover Talbot, Christine Van Broeckhoven, Michael Litt, Stylianos E. Antonarakis

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Abstract

A genetic linkage map of human chromosome 21q (HC21q) containing 43 markers genotyped by the polymerase chain reaction in the CEPH pedigrees is presented. The markers placed on this map are highly polymorphic with an average heterozygosity of 61%. The average interval size of the markers localized at 1000:1 odds is 2.5 cM. The map has a total length of 65.5 cM, with male and female lengths of 47.7 and 83.3 cM, respectively. The genotypes used in the construction of this map were subjected to rigorous error checking, which is reflected in the shorter map length compared to previous maps; the estimated error rate in genotyping is less than 0.04%. As noted in previous linkage maps there is increased recombination in females on proximal HC 21q and in the male in a region near the telomere. This map of HC 21 represents a highly informative and dense meiotic linkage map and will be useful in linking disease phenotypes to loci on this chromosome.

Original languageEnglish (US)
Pages (from-to)562-571
Number of pages10
JournalGenomics
Volume16
Issue number3
DOIs
StatePublished - Jun 1993

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ASJC Scopus subject areas

  • Genetics

Cite this

McInnis, M. G., Chakravarti, A., Blaschak, J., Petersen, M. B., Sharma, V., Avramopoulos, D., Blouin, J. L., König, U., Brahe, C., Matise, T. C., Warren, A. C., Talbot, C. C., Van Broeckhoven, C., Litt, M., & Antonarakis, S. E. (1993). A linkage map of human chromosome 21: 43 PCR markers at average intervals of 2.5 cM. Genomics, 16(3), 562-571. https://doi.org/10.1006/geno.1993.1231