A link between transcription and intermediary metabolism: A role for Sir2 in the control of acetyl-coenzyme A synthetase

V. J. Starai, H. Takahashi, J. D. Boeke, J. C. Escalante-Semerena

Research output: Contribution to journalArticle


The silent information regulator protein (Sir2) and its homologs (collectively known as sirtuins) are NAD+-dependent deacetylase enzymes involved in chromosome stability, gene silencing and cell aging in eukaryotes and archaea. The discovery that sirtuin-dependent protein deacetylation is a NAD+-consuming reaction established a link with the energy generation systems of the cell. This link to metabolism was recently extended to the post-translational control of the activity of short-chain fatty acyl-coenzyme A (adenosine monophosphate-forming) synthetases in bacteria and yeast. The crystal structure of the Sir protein complexed with a peptide of a protein substrate provided insights into how sirtuins interact with their protein substrates.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalCurrent Opinion in Microbiology
Issue number2
Publication statusPublished - Apr 2004



  • 2′-O-acetyl-adenosine diphosphate ribose
  • Acetyl-coenzyme A synthetase
  • Acs
  • Adenosine monophosphate
  • AMP
  • CoA
  • Coenzyme A
  • NAD
  • NADH
  • OAADPr
  • Oxidized nicotinamide adenine dinucleotide
  • Reduced NAD
  • Silent information regulator
  • Sir2

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

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