A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78

Yongquan Luo, Jeffery M. Long, Chengbiao Lu, Sic L. Chan, Edward L. Spangler, Paolo Mascarucci, Avraham Raz, Dan L. Longo, Mark P. Mattson, Donald K. Ingram, Nan Ping Weng

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroleukin (NLK) is a multifunctional protein involved in neuronal growth and survival, cell motility and differentiation, and glucose metabolism. We report herein that hippocampal expression of NLK and its receptor gp78 is associated with maze learning in rats. First, mRNA levels of NLK and gp78 were significantly increased in hippocampi of male Fischer-344 rats following training in the Stone T-maze and the Morris water maze. Second, a parallel increase was found in hippocampal NLK and gp78 proteins after maze learning. Third, NLK and gp78 mRNA and protein expression in hippocampus was reduced in a group of aged rats that showed more errors during the acquisition of the Stone maze task as compared with young rats. Finally, application of recombinant NLK to hippocampal neurons significantly enhanced glutamateinduced ion currents, functional molecular changes that have been correlated with learning in vivo. Taken together, our results identify a novel association of hippocampal expression of NLK and its receptor gp78 with rat maze learning. Interaction of NLK with gp78 and subsequent signalling may strengthen synaptic mechanisms underlying learning and memory formation.

Original languageEnglish (US)
Pages (from-to)354-361
Number of pages8
JournalJournal of Neurochemistry
Volume80
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • 14-Unit Stone T-maze
  • Aging
  • gp78
  • Hippocampus
  • Learning and memory
  • Neuroleukin

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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