Abstract
A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.
Original language | English (US) |
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Pages (from-to) | 75-77 |
Number of pages | 3 |
Journal | International journal of surgical pathology |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - Feb 13 2015 |
Keywords
- Alveolar rhabdomyosarcoma
- Bone marrow
- Cytogenetics
- Flow cytometry
- Immunohistochemistry
ASJC Scopus subject areas
- Surgery
- Anatomy
- Pathology and Forensic Medicine