Abstract
A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 75-77 |
| Number of pages | 3 |
| Journal | International Journal of Surgical Pathology |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 13 2015 |
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Keywords
- Alveolar rhabdomyosarcoma
- Bone marrow
- Cytogenetics
- Flow cytometry
- Immunohistochemistry
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor. / Kern, Jason B.; Hii, Anselm; Kruse, Matthew J.; Szabo, Zsolt; Argani, Pedram; Hibbard, Michele K.; Gladstone, Douglas; Meyer, Christian; Zheng, Rui; Borowitz, Michael J; Duffield, Amy S.
In: International Journal of Surgical Pathology, Vol. 23, No. 1, 13.02.2015, p. 75-77.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor
AU - Kern, Jason B.
AU - Hii, Anselm
AU - Kruse, Matthew J.
AU - Szabo, Zsolt
AU - Argani, Pedram
AU - Hibbard, Michele K.
AU - Gladstone, Douglas
AU - Meyer, Christian
AU - Zheng, Rui
AU - Borowitz, Michael J
AU - Duffield, Amy S
PY - 2015/2/13
Y1 - 2015/2/13
N2 - A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.
AB - A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.
KW - Alveolar rhabdomyosarcoma
KW - Bone marrow
KW - Cytogenetics
KW - Flow cytometry
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=84920772189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920772189&partnerID=8YFLogxK
U2 - 10.1177/1066896914553666
DO - 10.1177/1066896914553666
M3 - Article
C2 - 25305220
AN - SCOPUS:84920772189
VL - 23
SP - 75
EP - 77
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 1
ER -