A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor

Jason B. Kern, Anselm Hii, Matthew J. Kruse, Zsolt Szabo, Pedram Argani, Michele K. Hibbard, Douglas E. Gladstone, Christian Meyer, Rui Zheng, Michael J. Borowitz, Amy S. Duffield

Research output: Contribution to journalArticlepeer-review

Abstract

A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalInternational journal of surgical pathology
Volume23
Issue number1
DOIs
StatePublished - Feb 13 2015

Keywords

  • Alveolar rhabdomyosarcoma
  • Bone marrow
  • Cytogenetics
  • Flow cytometry
  • Immunohistochemistry

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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