A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor

Jason B. Kern; Anselm Hii; Matthew J. Kruse; Zsolt Szabo; Pedram Argani; Michele K. Hibbard; Douglas E. Gladstone; Christian Meyer; Rui Zheng; Michael J. Borowitz; Amy S. Duffield

doi:10.1177/1066896914553666

A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor

Jason B. Kern, Anselm Hii, Matthew J. Kruse, Zsolt Szabo, Pedram Argani, Michele K. Hibbard, Douglas E. Gladstone, Christian Meyer, Rui Zheng, Michael J. Borowitz, Amy S. Duffield

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.

Original language	English (US)
Pages (from-to)	75-77
Number of pages	3
Journal	International journal of surgical pathology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1177/1066896914553666
State	Published - Feb 13 2015

Keywords

Alveolar rhabdomyosarcoma
Bone marrow
Cytogenetics
Flow cytometry
Immunohistochemistry

ASJC Scopus subject areas

Anatomy
Surgery
Pathology and Forensic Medicine

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Kern, J. B., Hii, A., Kruse, M. J., Szabo, Z., Argani, P., Hibbard, M. K., Gladstone, D. E., Meyer, C., Zheng, R., Borowitz, M. J., & Duffield, A. S. (2015). A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor. International journal of surgical pathology, 23(1), 75-77. https://doi.org/10.1177/1066896914553666

A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor. / Kern, Jason B.; Hii, Anselm; Kruse, Matthew J.; Szabo, Zsolt ; Argani, Pedram; Hibbard, Michele K.; Gladstone, Douglas E.; Meyer, Christian; Zheng, Rui; Borowitz, Michael J.; Duffield, Amy S.

In: International journal of surgical pathology, Vol. 23, No. 1, 13.02.2015, p. 75-77.

Research output: Contribution to journal › Article › peer-review

Kern, Jason B. ; Hii, Anselm ; Kruse, Matthew J. ; Szabo, Zsolt ; Argani, Pedram ; Hibbard, Michele K. ; Gladstone, Douglas E. ; Meyer, Christian ; Zheng, Rui ; Borowitz, Michael J. ; Duffield, Amy S. / A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor. In: International journal of surgical pathology. 2015 ; Vol. 23, No. 1. pp. 75-77.

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abstract = "A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.",

keywords = "Alveolar rhabdomyosarcoma, Bone marrow, Cytogenetics, Flow cytometry, Immunohistochemistry",

author = "Kern, {Jason B.} and Anselm Hii and Kruse, {Matthew J.} and Zsolt Szabo and Pedram Argani and Hibbard, {Michele K.} and Gladstone, {Douglas E.} and Christian Meyer and Rui Zheng and Borowitz, {Michael J.} and Duffield, {Amy S.}",

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AU - Argani, Pedram

AU - Hibbard, Michele K.

AU - Gladstone, Douglas E.

AU - Meyer, Christian

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AU - Borowitz, Michael J.

AU - Duffield, Amy S.

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AB - A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.

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KW - Immunohistochemistry

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A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor

Abstract

Keywords

ASJC Scopus subject areas

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