A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task

Vaughn R. Steele; Eyal Aharoni; Gillian E. Munro; Vince D. Calhoun; Prashanth Nyalakanti; Michael C. Stevens; Godfrey Pearlson; Kent A. Kiehl

doi:10.1016/j.bbr.2013.06.001

A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task

Vaughn R. Steele, Eyal Aharoni, Gillian E. Munro, Vince D. Calhoun, Prashanth Nyalakanti, Michael C. Stevens, Godfrey Pearlson, Kent A. Kiehl

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

We report a functional magnetic resonance imaging (fMRI) study of healthy adult participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying successful and unsuccessful response inhibition using a large sample (N= 102). We identified a number of regions uniquely engaged during successful response inhibition, including a fronto-parietal network involving the anterior cingulate, supplementary motor areas, lateral and inferior prefrontal regions, and the inferior parietal lobule. Unique hemodynamic activity was also noted in the amygdala and in frontostriatal regions including the inferior frontal gyrus and portions of the basal ganglia. Also, contrasts were defined to explore three variants of hemodynamic response allowing for more specificity in identifying the underlying cognitive mechanisms of response inhibition. Addressing issues raised by prior small sample studies, we identified a stable set of regions involved in successful response inhibition. The present results help to incrementally refine the specificity of the neural correlates of response inhibition.

Original language	English (US)
Pages (from-to)	529-536
Number of pages	8
Journal	Behavioural Brain Research
Volume	256
DOIs	https://doi.org/10.1016/j.bbr.2013.06.001
State	Published - Nov 1 2013
Externally published	Yes

Keywords

FMRI
Go/NoGo
Response inhibition

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2013.06.001

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title = "A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task",

abstract = "We report a functional magnetic resonance imaging (fMRI) study of healthy adult participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying successful and unsuccessful response inhibition using a large sample (N= 102). We identified a number of regions uniquely engaged during successful response inhibition, including a fronto-parietal network involving the anterior cingulate, supplementary motor areas, lateral and inferior prefrontal regions, and the inferior parietal lobule. Unique hemodynamic activity was also noted in the amygdala and in frontostriatal regions including the inferior frontal gyrus and portions of the basal ganglia. Also, contrasts were defined to explore three variants of hemodynamic response allowing for more specificity in identifying the underlying cognitive mechanisms of response inhibition. Addressing issues raised by prior small sample studies, we identified a stable set of regions involved in successful response inhibition. The present results help to incrementally refine the specificity of the neural correlates of response inhibition.",

keywords = "FMRI, Go/NoGo, Response inhibition",

author = "Steele, {Vaughn R.} and Eyal Aharoni and Munro, {Gillian E.} and Calhoun, {Vince D.} and Prashanth Nyalakanti and Stevens, {Michael C.} and Godfrey Pearlson and Kiehl, {Kent A.}",

note = "Funding Information: The authors thank Craig Bennett, Matthew Shane, J. Michael Maurer, Lora Cope, Eric Claus, members of the Olin Neuropsychiatry Research Center, and members of the Mind Research Network. This research was supported in part by grants from the National Institute of Mental Health : 1 R01 MH070539-01 (PI: Kiehl), 1 R01 MH071896-01 (PI: Kiehl), RO1 DA020709 (PI: Pearlson), and P50-AA12870-05 (PI for Project 4: Pearlson). ",

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doi = "10.1016/j.bbr.2013.06.001",

language = "English (US)",

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AU - Steele, Vaughn R.

AU - Aharoni, Eyal

AU - Munro, Gillian E.

AU - Calhoun, Vince D.

AU - Nyalakanti, Prashanth

AU - Stevens, Michael C.

AU - Pearlson, Godfrey

AU - Kiehl, Kent A.

N1 - Funding Information: The authors thank Craig Bennett, Matthew Shane, J. Michael Maurer, Lora Cope, Eric Claus, members of the Olin Neuropsychiatry Research Center, and members of the Mind Research Network. This research was supported in part by grants from the National Institute of Mental Health : 1 R01 MH070539-01 (PI: Kiehl), 1 R01 MH071896-01 (PI: Kiehl), RO1 DA020709 (PI: Pearlson), and P50-AA12870-05 (PI for Project 4: Pearlson).

PY - 2013/11/1

Y1 - 2013/11/1

N2 - We report a functional magnetic resonance imaging (fMRI) study of healthy adult participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying successful and unsuccessful response inhibition using a large sample (N= 102). We identified a number of regions uniquely engaged during successful response inhibition, including a fronto-parietal network involving the anterior cingulate, supplementary motor areas, lateral and inferior prefrontal regions, and the inferior parietal lobule. Unique hemodynamic activity was also noted in the amygdala and in frontostriatal regions including the inferior frontal gyrus and portions of the basal ganglia. Also, contrasts were defined to explore three variants of hemodynamic response allowing for more specificity in identifying the underlying cognitive mechanisms of response inhibition. Addressing issues raised by prior small sample studies, we identified a stable set of regions involved in successful response inhibition. The present results help to incrementally refine the specificity of the neural correlates of response inhibition.

AB - We report a functional magnetic resonance imaging (fMRI) study of healthy adult participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying successful and unsuccessful response inhibition using a large sample (N= 102). We identified a number of regions uniquely engaged during successful response inhibition, including a fronto-parietal network involving the anterior cingulate, supplementary motor areas, lateral and inferior prefrontal regions, and the inferior parietal lobule. Unique hemodynamic activity was also noted in the amygdala and in frontostriatal regions including the inferior frontal gyrus and portions of the basal ganglia. Also, contrasts were defined to explore three variants of hemodynamic response allowing for more specificity in identifying the underlying cognitive mechanisms of response inhibition. Addressing issues raised by prior small sample studies, we identified a stable set of regions involved in successful response inhibition. The present results help to incrementally refine the specificity of the neural correlates of response inhibition.

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A large scale (N=102) functional neuroimaging study of response inhibition in a Go/NoGo task

Abstract

Keywords

ASJC Scopus subject areas

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