A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task

Vaughn R. Steele; Eric D. Claus; Eyal Aharoni; Carla Harenski; Vince D. Calhoun; Godfrey Pearlson; Kent A. Kiehl

doi:10.1016/j.bbr.2014.04.001

A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task

Vaughn R. Steele, Eric D. Claus, Eyal Aharoni, Carla Harenski, Vince D. Calhoun, Godfrey Pearlson, Kent A. Kiehl

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We report a functional magnetic resonance imaging (fMRI) study of 102 healthy participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying responses to errors in a large sample. We identified a number of regions engaged during error processing including the anterior cingulate, left lateral prefrontal areas and bilateral inferior frontal gyrus, and the subthalamic nucleus. The power afforded by the large cohort enabled identification of regions not consistently measured during Go/NoGo tasks thus helping to incrementally refine our understanding of the neural correlates of error processing. With the present fMRI results, in combination with our previous exploration of response inhibition (Steele et al.), we outline a comprehensive set of regions associated with both response inhibition and error processing.

Original language	English (US)
Pages (from-to)	127-138
Number of pages	12
Journal	Behavioural Brain Research
Volume	268
DOIs	https://doi.org/10.1016/j.bbr.2014.04.001
State	Published - Jul 15 2014
Externally published	Yes

Keywords

Error processing
FMRI
Go/NoGo
Response inhibition

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2014.04.001

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title = "A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task",

abstract = "We report a functional magnetic resonance imaging (fMRI) study of 102 healthy participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying responses to errors in a large sample. We identified a number of regions engaged during error processing including the anterior cingulate, left lateral prefrontal areas and bilateral inferior frontal gyrus, and the subthalamic nucleus. The power afforded by the large cohort enabled identification of regions not consistently measured during Go/NoGo tasks thus helping to incrementally refine our understanding of the neural correlates of error processing. With the present fMRI results, in combination with our previous exploration of response inhibition (Steele et al.), we outline a comprehensive set of regions associated with both response inhibition and error processing.",

keywords = "Error processing, FMRI, Go/NoGo, Response inhibition",

author = "Steele, {Vaughn R.} and Claus, {Eric D.} and Eyal Aharoni and Carla Harenski and Calhoun, {Vince D.} and Godfrey Pearlson and Kiehl, {Kent A.}",

note = "Funding Information: The authors thank Craig Bennett, Matthew Shane, J. Michael Maurer, Lora Cope, members of the Olin Neuropsychiatry Research Center, and members of the Mind Research Network. This research was supported in part by grants from the National Institute of Mental Health : 1 R01 MH070539-01 (PI: Kiehl), 1 R01 MH071896-01 (PI: Kiehl), RO1 DA020709 (PI: Pearlson), and P50-AA12870-05 (PI for Project 4: Pearlson). ",

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doi = "10.1016/j.bbr.2014.04.001",

language = "English (US)",

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AU - Steele, Vaughn R.

AU - Claus, Eric D.

AU - Aharoni, Eyal

AU - Harenski, Carla

AU - Calhoun, Vince D.

AU - Pearlson, Godfrey

AU - Kiehl, Kent A.

N1 - Funding Information: The authors thank Craig Bennett, Matthew Shane, J. Michael Maurer, Lora Cope, members of the Olin Neuropsychiatry Research Center, and members of the Mind Research Network. This research was supported in part by grants from the National Institute of Mental Health : 1 R01 MH070539-01 (PI: Kiehl), 1 R01 MH071896-01 (PI: Kiehl), RO1 DA020709 (PI: Pearlson), and P50-AA12870-05 (PI for Project 4: Pearlson).

PY - 2014/7/15

Y1 - 2014/7/15

N2 - We report a functional magnetic resonance imaging (fMRI) study of 102 healthy participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying responses to errors in a large sample. We identified a number of regions engaged during error processing including the anterior cingulate, left lateral prefrontal areas and bilateral inferior frontal gyrus, and the subthalamic nucleus. The power afforded by the large cohort enabled identification of regions not consistently measured during Go/NoGo tasks thus helping to incrementally refine our understanding of the neural correlates of error processing. With the present fMRI results, in combination with our previous exploration of response inhibition (Steele et al.), we outline a comprehensive set of regions associated with both response inhibition and error processing.

AB - We report a functional magnetic resonance imaging (fMRI) study of 102 healthy participants who completed a demanding Go/NoGo task. The primary purpose of this study was to delineate the neural systems underlying responses to errors in a large sample. We identified a number of regions engaged during error processing including the anterior cingulate, left lateral prefrontal areas and bilateral inferior frontal gyrus, and the subthalamic nucleus. The power afforded by the large cohort enabled identification of regions not consistently measured during Go/NoGo tasks thus helping to incrementally refine our understanding of the neural correlates of error processing. With the present fMRI results, in combination with our previous exploration of response inhibition (Steele et al.), we outline a comprehensive set of regions associated with both response inhibition and error processing.

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KW - Response inhibition

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A large scale (N=102) functional neuroimaging study of error processing in a Go/NoGo task

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Keywords

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