A large scale (N = 400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry

Shashwath A. Meda, Nicole R. Giuliani, Vince D. Calhoun, Kanchana Jagannathan, David J. Schretlen, Anne Pulver, Nicola Cascella, Matcheri Keshavan, Wendy Kates, Robert Buchanan, Tonmoy Sharma, Godfrey D. Pearlson

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Background: Many studies have employed voxel-based morphometry (VBM) of MRI images as an automated method of investigating cortical gray matter differences in schizophrenia. However, results from these studies vary widely, likely due to different methodological or statistical approaches. Objective: To use VBM to investigate gray matter differences in schizophrenia in a sample significantly larger than any published to date, and to increase statistical power sufficiently to reveal differences missed in smaller analyses. Methods: Magnetic resonance whole brain images were acquired from four geographic sites, all using the same model 1.5T scanner and software version, and combined to form a sample of 200 patients with both first episode and chronic schizophrenia and 200 healthy controls, matched for age, gender and scanner location. Gray matter concentration was assessed and compared using optimized VBM. Results: Compared to healthy controls, schizophrenia patients showed significantly less gray matter concentration in multiple cortical and subcortical regions, some previously unreported. Overall, we found lower concentrations of gray matter in regions identified in prior studies, most of which reported only subsets of the affected areas. Conclusions: Gray matter differences in schizophrenia are most comprehensively elucidated using a large, diverse and representative sample.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalSchizophrenia Research
Issue number1-3
StatePublished - Apr 2008


  • Gray matter
  • Multi-site
  • Schizophrenia
  • Structural MRI
  • Voxel based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'A large scale (N = 400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry'. Together they form a unique fingerprint.

Cite this