A large high-density lipoprotein enriched in apolipoprotein C-I: A novel biochemical marker in infants of lower birth weight and younger gestational age

Peter O. Kwiterovich, Steven L. Cockrill, Donna G. Virgil, Elizabeth S. Garrett, James Otvos, Carolyn Knight-Gibson, Petar Alaupovic, Trudy Forte, Lin Zhang, Zachlyn N. Farwig, Ronald D. Macfarlane

Research output: Contribution to journalArticle

Abstract

Context: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease. Objective: To determine if there are novel patterns of lipoprotein heterogeneity in low-birth-weight infants. Design, Setting, and Participants: Prospective study at a US medical center of a representative sample of infants (n = 163; 70 white and 93 black) born at 28 or more weeks of gestational age between January 3, 2000, and September 27, 2000. This sample constituted 20% of all infants born during the study period at this site. Main Outcome Measures: Plasma levels and particle sizes of lipoprotein subclasses and plasma concentrations of lipids, lipoproteins (high-density lipoprotein [HDL] and low-density lipoprotein [LDL]), and apolipoproteins. Results: An elevated lipoprotein peak of a particle with density between 1.062 and 1.072 g/mL was identified using physical-chemical methods. This subclass of large HDL was enriched in apolipoprotein C-I (apo C-I). Based on the amount of the apo C-I-enriched HDL peak, 156 infants were assigned to 1 of 4 groups: 0 (none detected), 17%; 1 (possibly present), 41%; 2 (probably present), 22%; 3 (elevated), 19%. Infants in group 3, compared with those in the other 3 groups, had significantly (P

Original languageEnglish (US)
Pages (from-to)1891-1899
Number of pages9
JournalJournal of the American Medical Association
Volume293
Issue number15
DOIs
StatePublished - Apr 20 2005

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Apolipoprotein C-I
HDL Lipoproteins
Birth Weight
Lipoproteins
Gestational Age
Biomarkers
Low Birth Weight Infant
Apolipoproteins
LDL Lipoproteins
Particle Size
Coronary Artery Disease
Cardiovascular Diseases
Molecular Weight
Outcome Assessment (Health Care)
Prospective Studies
Lipids

ASJC Scopus subject areas

  • Medicine(all)

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A large high-density lipoprotein enriched in apolipoprotein C-I : A novel biochemical marker in infants of lower birth weight and younger gestational age. / Kwiterovich, Peter O.; Cockrill, Steven L.; Virgil, Donna G.; Garrett, Elizabeth S.; Otvos, James; Knight-Gibson, Carolyn; Alaupovic, Petar; Forte, Trudy; Zhang, Lin; Farwig, Zachlyn N.; Macfarlane, Ronald D.

In: Journal of the American Medical Association, Vol. 293, No. 15, 20.04.2005, p. 1891-1899.

Research output: Contribution to journalArticle

Kwiterovich, PO, Cockrill, SL, Virgil, DG, Garrett, ES, Otvos, J, Knight-Gibson, C, Alaupovic, P, Forte, T, Zhang, L, Farwig, ZN & Macfarlane, RD 2005, 'A large high-density lipoprotein enriched in apolipoprotein C-I: A novel biochemical marker in infants of lower birth weight and younger gestational age', Journal of the American Medical Association, vol. 293, no. 15, pp. 1891-1899. https://doi.org/10.1001/jama.293.15.1891
Kwiterovich, Peter O. ; Cockrill, Steven L. ; Virgil, Donna G. ; Garrett, Elizabeth S. ; Otvos, James ; Knight-Gibson, Carolyn ; Alaupovic, Petar ; Forte, Trudy ; Zhang, Lin ; Farwig, Zachlyn N. ; Macfarlane, Ronald D. / A large high-density lipoprotein enriched in apolipoprotein C-I : A novel biochemical marker in infants of lower birth weight and younger gestational age. In: Journal of the American Medical Association. 2005 ; Vol. 293, No. 15. pp. 1891-1899.
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