A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines

Richard Carroll; Jen Tsun Lin; Emelyn Joy Dacquel; Joseph D. Mosca; Donald S. Burke; Daniel C. St. Louis

doi:10.1128/jvi.68.9.6047-6051.1994

A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines

Richard Carroll, Jen Tsun Lin, Emelyn Joy Dacquel, Joseph D. Mosca, Donald S. Burke, Daniel C. St. Louis

Research output: Contribution to journal › Comment/debate › peer-review

53 Scopus citations

Abstract

We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4⁺ cells. This HIV-1- based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4⁺ cells.

Original language	English (US)
Pages (from-to)	6047-6051
Number of pages	5
Journal	Journal of virology
Volume	68
Issue number	9
DOIs	https://doi.org/10.1128/jvi.68.9.6047-6051.1994
State	Published - Sep 1994
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.68.9.6047-6051.1994

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title = "A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines",

abstract = "We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1- based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.",

author = "Richard Carroll and Lin, {Jen Tsun} and Dacquel, {Emelyn Joy} and Mosca, {Joseph D.} and Burke, {Donald S.} and {St. Louis}, {Daniel C.}",

year = "1994",

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doi = "10.1128/jvi.68.9.6047-6051.1994",

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AU - Carroll, Richard

AU - Lin, Jen Tsun

AU - Dacquel, Emelyn Joy

AU - Mosca, Joseph D.

AU - Burke, Donald S.

AU - St. Louis, Daniel C.

PY - 1994/9

Y1 - 1994/9

N2 - We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1- based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.

AB - We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1- based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.

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A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines

Abstract

ASJC Scopus subject areas

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