A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines

Richard Carroll, Jen Tsun Lin, Emelyn Joy Dacquel, Joseph D. Mosca, Donald S. Burke, Daniel C. St. Louis

Research output: Contribution to journalComment/debatepeer-review

Abstract

We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1- based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.

Original languageEnglish (US)
Pages (from-to)6047-6051
Number of pages5
JournalJournal of virology
Volume68
Issue number9
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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