A human immunodeficiency virus controller with a large population of CD4+CD8+ double-positive T cells

Christine M. Durand; Robert W. Buckheit; Maria Salgado; Christopher W. Pohlmeyer; Victoria E. Walker-Sperling; Robert W. Hegarty; Richard F. Ambinder; Joel N. Blankson

doi:10.1093/ofid/ofv039

A human immunodeficiency virus controller with a large population of CD4⁺CD8⁺ double-positive T cells

Christine M. Durand, Robert W. Buckheit, Maria Salgado, Christopher W. Pohlmeyer, Victoria E. Walker-Sperling, Robert W. Hegarty, Richard F. Ambinder, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4⁺CD8⁺ T cells did not have strong antiviral activity.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofv039
State	Published - Apr 1 2015

Keywords

AIDS
Double-positive cells
Elite controllers
HIV
HIV controllers
Immune activation
Long-term nonprogressors
Viremic controllers

ASJC Scopus subject areas

Oncology
Clinical Neurology

Access to Document

10.1093/ofid/ofv039

Cite this

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title = "A human immunodeficiency virus controller with a large population of CD4+CD8+ double-positive T cells",

abstract = "Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4+CD8+ T cells did not have strong antiviral activity.",

keywords = "AIDS, Double-positive cells, Elite controllers, HIV, HIV controllers, Immune activation, Long-term nonprogressors, Viremic controllers",

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AU - Walker-Sperling, Victoria E.

AU - Hegarty, Robert W.

AU - Ambinder, Richard F.

AU - Blankson, Joel N.

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