A human immunodeficiency virus controller with a large population of CD4+CD8+ double-positive T cells

Christine M. Durand, Robert W. Buckheit, Maria Salgado, Christopher W. Pohlmeyer, Victoria E. Walker-Sperling, Robert W. Hegarty, Richard F. Ambinder, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4+CD8+ T cells did not have strong antiviral activity.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • AIDS
  • Double-positive cells
  • Elite controllers
  • HIV
  • HIV controllers
  • Immune activation
  • Long-term nonprogressors
  • Viremic controllers

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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